CARUSO MASSIMO

Ricercatore a tempo determinato Legge 240/10

Orari di ricevimento

Concordare un appuntamento via email con il docente.

Curriculum

Massimo Caruso

2020-act Assistant Professor of Biochemistry (RTDb) - University of Catania - Department of Biomedical and Biotechnological Science

2021 National scientific qualification to second-rate professor (associate professor) achieved in June 1st, 2021.

2019-2020 Assistant Professor of Biochemistry (RTDa) - University of Catania - Department of Biomedical and Biotechnological Science

2017-2020 Contract Professor - University of Catania - Department of Medical and Surgical Sciences and Advanced Technologies "G.F. Ingrassia" - Degree Course: “Biomedical Laboratory Technician”. SSD MED 04: Immunopathologies Techniques.

2017-2020. Contract Professor - University of Catania - Department of Medical and Surgical Sciences and Advanced Technologies "G.F. Ingrassia" - Degree Course: “Biomedical Laboratory Technician”. SSD MED 04: Immunopathology.

2016-2020. Contract Professor - University of Catania - Department of Medical and Surgical Sciences and Advanced Technologies "G.F. Ingrassia" - Degree Course: “Nursing Sciences”. SSD MED 04: General and Clinical Pathology .

2016-2017 Contract Professor - University of Catania - Department of Biological, Geological and Environmental Sciences - Degree Course: “Biological Sciences”. SSD BIO 06: Cytology and Histology.

2019-act. co-Principal Investigator (co-PI) for the international “Replica” project, multicentric study that aim to replicate in vitro studies in toxicology of smoke and smokeless products. Founded from ECLAT Srl.

2016-2020 Postdoctoral Research - University of Catania - Department of Clinical and Experimental Medicine

2014-2016. Principal Investigator Site for the University of Catania in the European Project “U-BIOPRED” (Unbiased BIOmarkers for the PREDiction of respiratory disease outcomes” – European Communities’s Seventh Framework Programme (FP7/2007-2013) – Innovative Medicine Initiative (IMI) (P.I. Prof Peter Sterk – Full professor of the Pathophysiology and Phenotyping of Asthma and COPD - Faculty of Medicine (Amsterdam Medical Centre of the Universiteit van Amsterdam (AMC-UvA)).

2011-2016 Researcher in 2 PO-FESR National supported research project in Allergy and Immunology. Institute for Medical and Environmental Research (IRMA) and University of Catania.

2006-2018 Thesis Correlator and Relator of over 40 Master's degree Thesis (Faculties of Pharmacy, Biology and Medicine).

2006-2007 Research Associate – Project “Study of cytokines profile in sputum from COPD patients” University of Catania - Department of Respiratory Diseases

2006 PhD in Respiratory Diseases – University of Catania. Thesis: "Oxidized Low Density Lipoproteins Promote Eosinophil Activation". Tutor: Prof. Carlo Vancheri. Coordinator: Prof. Ugo Giuseppe Di Maria
2001. Master’s Degree in Biological Sciences, University of Catania. Thesis: "Detection of Enterovirus RNA in the first diagnosis of juvenile diabetes”. Supervisor: Prof. Guido Scalia


PROFESSIONAL EXPERIENCE:

2019-act Assistant Professor - University of Catania - Department of Biomedical and Biotechnological Science

2018-2020 Visiting Researcher - University of Catania - Department of Biomedical and Biotechnological Sciences (BIOMETEC)

2016-2020 Postdoctoral Research Fellow - University of Catania - Department of Clinical and Experimental Medicine (Asthma and Immunology studies)

2011-2016 Research Consultant - University of Catania - Department of Clinical and Experimental Medicine (Asthma and Immunology studies)

2013-2015 Researcher – IRMA Srl. – Principal Investigator site - Project: ALI.FU.ID.E.A. (FUntional Foods and Nutraceutical Supplements based on White Lupine and Citrus derivatives) – Project funded by a National Grant: POR FESR Sicilia 2007-2013 Linea di intervento 4.1.1.1 (P.I. for the partner – IRMA Srl).

2012-act Research Consultant – LIAF (Lega Italiana Antifumo – Italian Anti-Smoking League)

2012-2013 Research Consultant – IRMA Srl - Project: S.A.M.A.R.A. (Sistema Aerobiologico Molecolare e Analisi di Reattività Ambientale - Molecular Aerobiological System and Environmental Reactivity Analysis) – Project funded by a National Grant (PO FESR 2007/2013 - Avviso 2011 - Asse IV, Obiettivo Operativo 4.1.1 Linea di Intervento 4.1.1.2 (GURS n. 14 del 1/04/2011 e D.D.G. 2068/3 in GURS n. 23 del 27/05/2010).

2012-2012 Technical Director - I.R.M.A. (Istituto di Ricerca Medica ed Ambientale – Institute for Medical and Environmental Research) S.r.l – Registered in the National Register of Research Laboratories - Decree of Ministry of Education, University and Research n° 1417 GU n° 160 – 12/07/2005.

2010-2012 Senior Researcher - I.R.M.A. (Istituto di Ricerca Medica ed Ambientale – Institute for Medical and Environmental Research) S.r.l – Registered in the National Register of Research Laboratories - Decree of Ministry of Education, University and Research n° 1417 GU n° 160 – 12/07/2005.

2009-2010 Senior Research Consultant for the project “Bionetwork” – “Group: Red Biotechnology” (Biotechnologies applied to human health) - Biosistema S.c.r.l., public-private capital company and owner of the “Technological Competence Center for Advanced Biology” – Coordinated by Università degli Studi di Sassari, 07100 Sassari (SS)

2006-2011 Researcher - I.R.M.A. (Istituto di Ricerca Medica ed Ambientale – Institute for Medical and Environmental Research) S.r.l – Registered in the National Register of Research Laboratories - Decree of Ministry of Education, University and Research n° 1417 GU n° 160 – 12/07/2005.

2006-2011 Laboratory Manager - I.R.M.A. (Istituto di Ricerca Medica ed Ambientale) S.r.l – Iscritto all'Albo Nazionale dei Laboratori di Ricerca – Decree of MIUR n° 1417 GU n° 160 del 12/07/2005.

REVIEWER FOR SCIENTIFIC JOURNALS, among which:
- International Journal of Chronic Obstructive Pulmonary Disease
- International Immunopharmacology
- Therapeutic Advances in Chronic Disease
- BMC Public Health
- PLOS ONE
- Frontiers in Phisiology
- Toxics

EDITORIAL POSITIONS:
- Frontiers in Physiology - Associate Editor in Respiratory Physiology and Pathophysiology
- BMC Public Health - Associate Editor (resigned since April 2023)
- International Journal of Environmental Research and Public Health – Associate Editor (resigned since February 2023)

REVIEWER FOR GRANT PROGRAMME:
- 2nd e 3rd Call of the Fellowship International Program WHRI-ACADEMY (FP7 Marie Curie COFOUND scheme)
- European Respiratory Society Fellowship Grant (2017-2018)

SPEAKER AND CHAIRMAN for a number of national and international symposia (EAACI, AAAAI, ERS, SiBioC).

GRANTS:
• 2012 AAAAI Fellow in Training International Travel Grant Scholarship (American Academy of Allergy, Asthma and Immunology)
• 2014 AAAAI Fellow in Training International Travel Grant Scholarship (American Academy of Allergy, Asthma and Immunology)
• 2014 Alain de Weck Travel Grant - 30th Symposium of the CIA (Collegium International Allergologicum) - Petersberg, Germany, 13- 18 September 2014.

PATENTS:
• Italian Patent for the industrial invention N. 0001420985 del 19/02/2016 “Method and Kit for in vitro diagnostics of "delayed" adverse drug reactions”. Application N. 102011901953669/FI2011A000120 submitted on June 13rd 2011 (obtained on June 2016).

SCIENTIFIC PUBLICATIONS
(H index = 27; Total citations = 3219 as reported by Scopus, May 25th, 2023)
1. Hou, R., Ye, G., Cheng, X., Shaw, D.E., Bakke, P.S., Caruso, M., Dahlen, B., Dahlen, S.-E., Fowler, S.J., Horváth, I., Howarth, P., Krug, N., Montuschi, P., Sanak, M., Sandström, T., Auffray, C., De Meulder, B., Sousa, A.R., Adcock, I.M., Fan Chung, K., Sterk, P.J., Skipp, P.J., Schofield, J., Djukanović, R. The role of inflammation in anxiety and depression in the European U-BIOPRED asthma cohorts. (2023) Brain, Behavior, and Immunity, 111, pp. 249-258. DOI: 10.1016/j.bbi.2023.04.011
2. Fuochi, V., Floresta, G., Emma, R., Patamia, V., Caruso, M., Zagni, C., Ronchi, F., Ronchi, C., Drago, F., Rescifina, A., Furneri, P.M. Heparan Sulfate and Enoxaparin Interact at the Interface of the Spike Protein of HCoV-229E but Not with HCoV-OC43. (2023) Viruses, 15 (3), art. no. 663. DOI: 10.3390/v15030663
3. Brandsma, J., Schofield, J.P.R., Yang, X., Strazzeri, F., Barber, C., Goss, V.M., Koster, G., Bakke, P.S., Caruso, M., Chanez, P., Dahlén, S.-E., Fowler, S.J., Horváth, I., Krug, N., Montuschi, P., Sanak, M., Sandström, T., Shaw, D.E., Chung, K.F., Singer, F., Fleming, L.J., Adcock, I.M., Pandis, I., Bansal, A.T., Corfield, J., Sousa, A.R., Sterk, P.J., Sánchez-García, R.J., Skipp, P.J., Postle, A.D., Djukanović, R., the U-BIOPRED Study Group. Stratification of asthma by lipidomic profiling of induced sputum supernatant. (2023) Journal of Allergy and Clinical Immunology. DOI: 10.1016/j.jaci.2023.02.032
4. Caponnetto, P., Campagna, D., Maglia, M., Benfatto, F., Emma, R., Caruso, M., Caci, G., Busà, B., Pennisi, A., Ceracchi, M., Migliore, M., Signorelli, M. Comparing the Effectiveness, Tolerability, and Acceptability of Heated Tobacco Products and Refillable Electronic Cigarettes for Cigarette Substitution (CEASEFIRE): Randomized Controlled Trial (2023) JMIR Public Health and Surveillance, 9, art. no. e42628. DOI: 10.2196/42628
5. Longhitano L, Vicario N, Forte S, Giallongo C, Broggi G, Caltabiano R, Barbagallo GMV, Altieri R, Raciti G, Di Rosa M, Caruso M, Parenti R, Liso A, Busi F, Lolicato M, Mione MC, Li Volti G, Tibullo D. Lactate modulates microglia polarization via IGFBP6 expression and remodels tumor microenvironment in glioblastoma. Cancer Immunol Immunother. 2023 Jan;72(1):1-20. doi: 10.1007/s00262-022-03215-3. Epub 2022 Jun 3. Erratum in: Cancer Immunol Immunother. 2022 Jul 12;: PMID: 35654889; PMCID: PMC9813126.
6. Emma R+, Caruso M+, Campagna D, Pulvirenti R, Li Volti G. The Impact of Tobacco Cigarettes, Vaping Products and Tobacco Heating Products on Oxidative Stress. Antioxidants (Basel). 2022 Sep 16;11(9):1829. doi: 10.3390/antiox11091829. PMID: 36139904; PMCID: PMC9495690.
7. Brandsma J, Schofield JPR, Yang X, Strazzeri F, Barber C, Goss VM, Koster G, Bakke PS, Caruso M, Chanez P, Dahlén SE, Fowler SJ, Horváth I, Krug N, Montuschi P, Sanak M, Sandström T, Shaw DE, Chung KF, Singer F, Fleming LJ, Adcock IM, Pandis I, Bansal AT, Corfield J, Sousa AR, Sterk PJ, Sánchez-García RJ, Skipp PJ, Postle AD, Djukanović R; U-BIOPRED Study Group. Stratification of asthma by lipidomic profiling of induced sputum supernatant. J Allergy Clin Immunol. 2023 Mar 12:S0091-6749(23)00293-2. doi: 10.1016/j.jaci.2023.02.032. Epub ahead of print. PMID: 36918039.
8. Hoda U, Pavlidis S, Bansal AT, Takahashi K, Hu S, Ng Kee Kwong F, Rossios C, Sun K, Bhavsar P, Loza M, Baribaud F, Chanez P, Fowler SJ, Horvath I, Montuschi P, Singer F, Musial J, Dahlen B, Krug N, Sandstrom T, Shaw DE, Lutter R, Fleming LJ, Howarth PH, Caruso M, Sousa AR, Corfield J, Auffray C, De Meulder B, Lefaudeux D, Dahlen SE, Djukanovic R, Sterk PJ, Guo Y, Adcock IM, Chung KF; U- BIOPRED study group. Clinical and transcriptomic features of persistent exacerbation-prone severe asthma in U-BIOPRED cohort. Clin Transl Med. 2022 Apr;12(4):e816. doi: 10.1002/ctm2.816. PMID: 35474304; PMCID: PMC9043117.
9. Maglia M, Quattropani MC, Polosa R, Panassidi A, Caruso M, Mangione M, Nicolosi V, Mazzeppi SD, Lenzo V, Sardella A, Caponnetto P. Qualitative study on the perception of combustible cigarettes, e- cigarettes and heated tobacco cigarettes among pregnant women. J Addict Dis. 2023 Mar 9:1-11. doi: 10.1080/10550887.2023.2184302. Epub ahead of print. PMID: 36892131.
10. Caruso M, Emma R, Distefano A, Rust S, Poulas K, Giordano A, Volarevic V, Mesiakaris K, Boffo S, Arsenijevic A, Karanasios G, Pulvirenti R, Ilic A, Canciello A, Zuccarello P, Ferrante M, Polosa R, Li Volti G. Comparative assessment of electronic nicotine delivery systems aerosol and cigarette smoke on endothelial cell migration: the Replica Project. Drug Test Anal. 2022 Jul 25. doi: 10.1002/dta.3349. Epub ahead of print. PMID: 35877466.
11. Hajat, C., Stein, E., Selya, A., Polosa, R., Alaimo, S., Anfuso, C.D., Barbagallo, I., Basile, F., Battiato, S., Benhamou, B., Bertino, G., Bianchi, A., Biondi, A.G., Brandi, M.L., Cacciola, E., Cacciola, R.R., Cacopardo, B.S., Calogero, A.E., Cambria, M.T., Campagna, D., Caraci, F., Cariola, A., Caruso, M., Caponnetto, P., Ciancio, A., Cibella, F., Mauro, M., Piazza, J., Stefano, A., Drago, F., Failla, S., Faraci, R., Ferlito, S., Ferrante, M., Ferro, A., Ferro, G.A., Frasca, F., Frittitta, L., Furneri, P.M., Gagliano, A., Gallo, G., Galvano, F., Grasso, G., Guarino, F., Gulino, A., Jannini, E.A., Vignera, S.L., Lazzarino, G., Ledda, C., Leonardi, R.M., Volti, G.L., Longo, A., Lupo, G., Malerba, M., Marletta, L., Nicolosi, G., Nocera, F., Conti, G.O., Palazzo, G., Parenti, R., Pedullà, E., Pulvirenti, A., Purrello, F., Rapisarda, F., Rapisarda, V., Rizzo, R., Ronsisvalle, S., Ronsisvalle, G., Ruggieri, M., Santagati, M.C., Satriano, C., Sciacca, L., Signorelli, M.S., Tatullo, M., Tibullo, D., Tomaselli, V., Volarevic, V., Zanoli, L., Zappalà, A., The CoEHAR study group. Analysis of common methodological flaws in the highest cited e-cigarette epidemiology research. (2022) Internal and Emergency Medicine, 17 (3), pp. 887-909. DOI: 10.1007/s11739-022-02967-1
12.Tiotiu, A., Badi, Y., Kermani, N.Z., Sanak, M., Kolmert, J., Wheelock, C.E., Hansbro, P.M., Dahlén, S.-E., Sterk, P.J., Djukanovic, R., Guo, Y., Mumby, S., Adcock, I.M., Chung, K.F., Hoda, U., Rossios, C., Bel, E., Rao, N., Myles, D., Compton, C., Van Geest, M., Howarth, P., Roberts, G., Lefaudeux, D., De Meulder, B., Bansal, A.T., Knowles, R., Erzen, D., Wagers, S., Krug, N., Higenbottam, T., Matthews, J., Erpenbeek, V., Carayannopoulos, L., Roberts, A., Supple, D., deBoer, P., Caruso, M., Chanez, P., Horváth, I., Musial, J., Sandström, T., U-BIOPRED Consortium Project Team Association of Differential Mast Cell Activation with Granulocytic Inflammation in Severe Asthma (2022) American Journal of Respiratory and Critical Care Medicine, 205 (4), pp. 397-411. DOI: 10.1164/rccm.202102-0355OC
13.Alba A, Villaggio G, Messina GML, Caruso M, Federico C, Cambria MT, Marletta G, Sinatra F. Cytostatic Effects of Polyethyleneimine Surfaces on the Mesenchymal Stromal Cell Cycle. Polymers (Basel). 2022 Jun 29;14(13):2643. doi: 10.3390/polym14132643. PMID: 35808689; PMCID: PMC9269326.
14. Caruso, M., Emma, R., Distefano, A. Rust S, Poulas K, Zadjali F, Giordano A, Volarevic V, Mesiakaris K, Al Tobi M, Boffo S, Arsenijevic A, Zuccarello P, Ferrante M, Polosa R, Li Volti G and the Replica Project Group. Electronic nicotine delivery systems exhibit reduced bronchial epithelial cells toxicity compared to cigarette: the Replica Project. Sci Rep 11, 24182 (2021). https://doi.org/10.1038/s41598- 021-03310-y
15. Abdel-Aziz MI, Vijverberg SJH, Neerincx AH, Brinkman P, Wagener AH, Riley JH, Sousa AR, Bates S, Wagers SS, De Meulder B, Auffray C, Wheelock ÅM, Bansal AT, Caruso M, Chanez P, Uddin M, Corfield J, Horvath I, Krug N, Musial J, Sun K, Shaw DE, Sandström T, Montuschi P, Fowler SJ, Lutter R, Djukanovic R, Howarth P, Skipp P, Sanak M, Adcock IM, Chung KF, Sterk PJ, Kraneveld AD, Maitland-van der Zee PharmD AH; U-BIOPRED Study Group. A multi-omics approach to delineate sputum microbiome-associated asthma inflammatory phenotypes. Eur Respir J. 2021 Nov 25:2102603. doi: 10.1183/13993003.02603-2021. Epub ahead of print. PMID: 34824056.
16.Reinke SN, Naz S, Chaleckis R, Gallart-Ayala H, Kolmert J, Kermani NZ, Tiotiu A, Broadhurst DI, Lundqvist A, Olsson H, Ström M, Wheelock ÅM, Gómez C, Ericsson M, Sousa AR, Riley JH, Bates S, Scholfield J, Loza M, Baribaud F, Bakke PS, Caruso M, Chanez P, Fowler SJ, Geiser T, Howarth P, Horváth I, Krug N, Montuschi P, Behndig A, Singer F, Musial J, Shaw DE, Dahlén B, Hu S, Lasky-Su J, Sterk PJ, Chung KF, Djukanovic R, Dahlén SE, Adcock IM, Wheelock CE; U-BIOPRED Study Group#. Urinary metabotype of severe asthma evidences decreased carnitine metabolism independent of oral corticosteroid treatment in the U-BIOPRED study. Eur Respir J. 2021 Nov 25:2101733. doi: 10.1183/13993003.01733-2021. Epub ahead of print. PMID: 34824054.
17. Mikus MS, Kolmert J, Andersson LI, Östling J, Knowles RG, Gómez C, Ericsson M, Thörngren JO, Khoonsari PE, Dahlén B, Kupczyk M, De Meulder B, Auffray C, Bakke PS, Beghe B, Bel EH, Caruso M, Chanez P, Chawes B, Fowler SJ, Gaga M, Geiser T, Gjomarkaj M, Horváth I, Howarth PH, Johnston SL, Joos G, Krug N, Montuschi P, Musial J, Niżankowska-Mogilnicka E, Olsson HK, Papi A, Rabe KF, Sandström T, Shaw DE, Siafakas NM, Uhlen M, Riley JH, Bates S, Middelveld RJM, Wheelock CE, Chung KF, Adcock IM, Sterk PJ, Djukanovic R, Nilsson P, Dahlén SE, James A; U–BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Disease outcome) Study Group; BIOAIR (Longitudinal Assessment of Clinical Course and Biomarkers in Severe Chronic Airway Disease) Consortium. Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation. Eur Respir J. 2021 Nov 4:2100142. doi: 10.1183/13993003.00142-2021. Epub ahead of print. PMID: 34737220.
18.Caruso M, Emma R, Rust S, Distefano A, Carota G, Pulvirenti R, Polosa R, Li Volti G. Screening of different cytotoxicity methods for the assessment of ENDS toxicity relative to tobacco cigarettes. Regul Toxicol Pharmacol. 2021 Oct;125:105018. doi: 10.1016/j.yrtph.2021.105018. Epub 2021 Jul 24. PMID: 34314750.
19.Polosa R, Emma R, Cibella F, Caruso M, Conte G, Benfatto F, Ferlito S, Gulino A, Malerba M, Caponnetto P. Impact of exclusive e-cigarettes and heated tobacco products use on muco-ciliary clearance. Ther Adv Chronic Dis. 2021 Aug 12;12:20406223211035267. doi: 10.1177/20406223211035267. PMID: 34422253; PMCID: PMC8371723.
20. Caruso M, Distefano A, Emma R, Di Rosa M, Carota G, Rust S, Polosa R, Zuccarello P, Ferrante M, Raciti G, Li Volti G. Role of Cigarette Smoke on Angiotensin-Converting Enzyme-2 Protein Membrane Expression in Bronchial Epithelial Cells Using an Air-Liquid Interface Model. Front Pharmacol. 2021 Mar 30;12:652102. doi: 10.3389/fphar.2021.652102. PMID: 33859566; PMCID: PMC8042260.
21. Badi YE, Pavel AB, Pavlidis S, Riley JH, Bates S, Kermani NZ, Knowles R, Kolmert J, Wheelock CE, Worsley S, Uddin M, Alving K, Bakke PS, Behndig A, Caruso M, Chanez P, Fleming LJ, Fowler SJ, Frey U, Howarth P, Horváth I, Krug N, Maitland-van der Zee AH, Montuschi P, Roberts G, Sanak M, Shaw DE, Singer F, Sterk PJ, Djukanovic R, Dahlen SE, Guo YK, Chung KF, Guttman-Yassky E, Adcock IM; U-BIOPRED Study Group. Mapping atopic dermatitis and anti-IL-22 response signatures to type 2-low severe neutrophilic asthma. (2022) Journal of Allergy and Clinical Immunology, 149 (1), pp. 89-101. DOI: 10.1016/j.jaci.2021.04.010
22. Zuccarello P, Rust S, Caruso M (corr. Author), Emma R, Pulvirenti R, Favara C, Polosa R, Li Volti G, Ferrante M. Nicotine dosimetry and stability in cambridge filter PADs (CFPs) following different smoking regime protocols and storage conditions. Regul Toxicol Pharmacol. 2021 Jun;122:104917. doi: 10.1016/j.yrtph.2021.104917. Epub 2021 Mar 18. PMID: 33744373.
23.O'Leary R, Polosa R, Li Volti G; Center of Excellence for the Acceleration of Harm Reduction (CoEHAR). Critical appraisal of the European Union Scientific Committee on Health, Environmental and Emerging Risks (SCHEER) Preliminary Opinion on electronic cigarettes. Harm Reduct J. 2021 Mar 10;18(1):31. doi: 10.1186/s12954-021-00476-6. PMID: 33691708; PMCID: PMC7945356.
24. Alahmadi FH, Simpson AJ, Gomez C, Ericsson M, Thörngren JO, Wheelock C, Shaw DE, Fleming LJ, Roberts G, Riley J, Bates S, Sousa AR, Knowles R, Bansal AT, Corfield J, Pandis I, Sun K, Bakke PS, Caruso M, Chanez P, Dahlén B, Horvath I, Krug N, Montuschi P, Singer F, Wagers S, Adcock IM, Djukanovic R, Chung KF, Sterk PJ, Dahlen SE, Fowler SJ; U-BIOPRED Study Group. Medication Adherence in Patients with Severe Asthma Prescribed Oral Corticosteroids in the U-BIOPRED Cohort. Chest. 2021 Feb 19:S0012-3692(21)00288-9. doi: 10.1016/j.chest.2021.02.023. Epub ahead of print. PMID: 33610577.
25. Kermani NZ, Song WJ, Badi Y, Versi A, Guo Y, Sun K, Bhavsar P, Howarth P, Dahlen SE, Sterk PJ, Djukanovic R, Adcock IM, Chung KF; U-BIOPRED Consortium: Uruj Hoda, Christos Rossios, Elisabeth Bel, Navin Rao, David Myles, Chris Compton, Marleen Van Geest, Peter Howarth, Graham Roberts, Diane Lefaudeux, Bertrand De Meulder, Aruna T Bansal, Richard Knowles, Damijn Erzen, Scott Wagers, Norbert Krug, Tim Higenbottam, John Matthews, Veit Erpenbeek, Leon Carayannopoulos, Amanda Roberts, David Supple, Pim deBoer, Massimo Caruso, Pascal Chanez, Sven-Erik Dahlen, Ildikó Horváth, Nobert Krug, Jacek Musial, Thomas Sandström. Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma. Respir Res. 2021 Jan 7;22(1):10. doi: 10.1186/s12931-020-01605-8. Erratum in: Respir Res. 2021 Feb 8;22(1):47. PMID: 33413387; PMCID: PMC7788167. (Correction in Respir Res. 22(1),47)
26.Kolmert J, Gómez C, Balgoma D, et al. Urinary Leukotriene E4 and Prostaglandin D2 Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type-2 Inflammation [published online ahead of print, 2020 Jul 15]. Am J Respir Crit Care Med. 2020;10.1164/rccm.201909-1869OC. doi:10.1164/rccm.201909-1869OC
27. Corona D, Ekser B, Gioco R, et al. Heme-Oxygenase and Kidney Transplantation: A Potential for Target Therapy?. Biomolecules. 2020;10(6):840. Published 2020 May 30. doi:10.3390/biom10060840
28. Caruso M, Fabroni S, Emma R, et al. A new standardized phytoextract from red orange and lemon wastes (red orange and lemon extract) reduces basophil degranulation and activation [published online ahead of print, 2020 May 6]. Nat Prod Res. 2020;1-6. doi:10.1080/14786419.2020.1761355
29. Li Volti G, Caruso M, Polosa R. Smoking and SARS-CoV-2 Disease (COVID-19): Dangerous Liaisons or Confusing Relationships?.J Clin Med. 2020;9(5):1321. Published 2020 May 2. doi:10.3390/jcm9051321
30. Castracani CC, Longhitano L, Distefano A, Di Rosa M, Pittalà V, Lupo G, Caruso M, Corona D, Tibullo D, Li Volti G. Heme Oxygenase-1 and Carbon Monoxide Regulate Growth and Progression in Glioblastoma Cells. Mol Neurobiol. 2020 Feb 27. doi: 10.1007/s12035-020-01869-7. [Epub ahead of print] PubMed PMID: 32108290.
31. Castracani CC, Longhitano L, Distefano A, Anfuso D, Kalampoka S, La Spina E, Astuto M, Avola R, Caruso M, Nicolosi D, Giallongo C, Tibullo D, Volti GL. Role of 17β-Estradiol on Cell Proliferation and Mitochondrial Fitness in Glioblastoma Cells. J Oncol. 2020 Feb 14;2020:2314693. doi: 10.1155/2020/2314693. eCollection 2020. PubMed PMID: 32148493; PubMed Central PMCID: PMC7042539.
32.Caponnetto P, Caruso M, Maglia M, Emma R, Saitta D, Busà B, Polosa R, Prosperini U, Pennisi A, Benfatto F, Sartorio C, Guastella M, Mondati E. Non-inferiority trial comparing cigarette consumption, adoption rates, acceptability, tolerability, and tobacco harm reduction potential in smokers switching to Heated Tobacco Products or electronic cigarettes: Study protocol for a randomized controlled trial. Contemp Clin Trials Commun. 2020 Jan 8;17:100518. doi: 10.1016/j.conctc.2020.100518. eCollection 2020 Mar. PubMed PMID: 31956726; PubMed Central PMCID: PMC6962654.
33. Cruz AA, Riley JH, Bansal AT, Ponte EV, Souza-Machado A, Almeida PCA, Biao-Lima V, Davis M, Bates S, Adcock IM, Sterk PJ, Chung KF; ProAR Study Group; U-BIOPRED Study Groups. Asthma similarities across ProAR (Brazil) and U-BIOPRED (Europe) adult cohorts of contrasting locations, ethnicity and socioeconomic status. Respir Med. 2019 Nov 26;161:105817. doi: 10.1016/j.rmed.2019.105817.
34. Emma R, Polosa R, Caruso M*. High nicotine exposure in rodents is unlikely to inform about its toxicity in humans. Eur Respir J. 2019 Aug 29;54(2). pii:1801073. doi: 10.1183/13993003.01073-2018. Print 2019 Aug. PubMed PMID: 31467183.
35.Polosa R, O'Leary R, Tashkin D, Emma R, Caruso M. The effect of e-cigarette aerosol emissions on respiratory health: a narrative review. Expert Rev Respir Med. 2019 Sep;13(9):899-915. doi: 10.1080/17476348.2019.1649146. Epub 2019 Aug PubMed PMID: 31375047.
36. Östling J., van Geest M., Schofield J.P.R., Jevnikar Z., Wilson S., Ward J., Lutter R., Shaw D.E., Bakke P.S., Caruso M., Dahlen S.-E., Fowler S.J., Horváth I., Krug N., Montuschi P., Sanak M., Sandström T., Sun K., Pandis I., Auffray C., Sousa A.R., Guo Y., Adcock I.M., Howarth P., Chung K.F., Bigler J., Sterk P.J., Skipp P.J., Djukanović R., Vaarala, O., Adcock I.M., Ahmed, H. IL-17–high asthma with features of a psoriasis immunophenotype. Journal of Allergy and Clinical Immunology. Volume 144, Issue 5, November 2019, Pages 1198-1213
37.Mathieu Césaire, Utpal Ghosha, Jean-Baptiste Austry, Etienne Mullere, Francesco Paolo Cammarata, Marilyne Guillamini, Massimo Caruso, Laurent Castérae, Giada Petringa, Giuseppe Antonio Pablo Cirrone, François Chevalier. Sensitization of chondrosarcoma cells with PARP inhibitor and high-LET radiation. Journal of Bone Oncology 17 (2019) 100246 https://doi.org/10.1016/j.jbo.2019.100246
38. JM, Schofield JPR, Wilson SJ, Ward J, Brandsma J, Strazzeri F, Bansal A, Yang X, Rowe A, Corfield J, Lutter R, Shaw DE, Bakke PS, Caruso M, Dahlén B, Fowler SJ, Horváth I, Howarth P, Krug N, Montuschi P, Sanak M, Sandström T, Sun K, Pandis I, Auffray C, De Meulder B, Lefaudeux D, Riley JH, Perotin Sousa AR, Dahlen SE, Adcock IM, Chung KF, Sterk PJ, Skipp PJ, Collins JE, Davies DE, Djukanović R; U-BIOPRED Study Group. Epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux. Eur Respir J. 2019 Jun 27;53(6). pii:1900453. doi: 10.1183/13993003.00453-2019. Print 2019 Jun. PubMed PMID: 31023846.
39. Tariq K, Schofield JPR, Nicholas BL, Burg D, Brandsma J, Bansal AT, Wilson SJ, Lutter R, Fowler SJ, Bakke, Caruso M, Dahlen B, Horváth I, Krug N, Montuschi P, Sanak M, Sandström T, Geiser T, Pandis I, Sousa AR, Adcock IM, Shaw DE, Auffray C, Howarth PH, Sterk PJ, Chung KF, Skipp PJ, Dimitrov B, Djukanović R; U-BIOPRED Study Group. Sputum proteomic signature of gastro-oesophageal reflux in patients with severe asthma. Respir Med. 2019 Apr;150:66-73. doi:10.1016/j.rmed.2019.02.008.
40. Schofield JPR, Burg D, Nicholas B, Strazzeri F, Brandsma J, Staykova D, Folisi C, Bansal AT, Xian Y, Guo Y, Rowe A, Corfield J, Wilson S, Ward J, Lutter R, Shaw DE, Bakke PS, Caruso M, Dahlen SE, Fowler SJ, Horváth I, Howarth P, Krug N, Montuschi P, Sanak M, Sandström T, Sun K, Pandis I, Riley J, Auffray C, De Meulder B, Lefaudeux D, Sousa AR, Adcock IM, Chung KF, Sterk PJ, Skipp PJ, Djukanović R; U-BIOPRED Study Group. Stratification of asthma phenotypes by airway proteomic signatures. J Allergy Clin Immunol. 2019 Mar 28. pii:S0091-6749(19)30415-4. doi: 10.1016/j.jaci.2019.03.013.
41. Morjaria JB, Emma R, Fuochi V, Polosa R, Caruso M*. An evaluation of mepolizumab for the treatment of severe asthma. Expert Opin Biol Ther. 2019 Jun;19(6):491-500. doi: 10.1080/14712598.2019.1610382.
42.Emma R, Morjaria JB, Fuochi V, Polosa R, Caruso M*. Mepolizumab in the management of severe eosinophilic asthma in adults: current evidence and practical experience. Ther Adv Respir Dis. 2018 Jan- Dec;12:1753466618808490. doi: 10.1177/1753466618808490.
43. Brinkman P, Wagener AH, Hekking PP, Bansal AT, Maitland-van der Zee AH, Wang Y, Weda H, Knobel HH, Vink TJ, Rattray NJ, D'Amico A, Pennazza G, Santonico M, Lefaudeux D, De Meulder B, Auffray C, Bakke PS, Caruso M, Chanez P, Chung KF, Corfield J, Dahlén SE, Djukanovic R, Geiser T, Horvath I, Krug N, Musial J, Sun K, Riley JH, Shaw DE, Sandström T, Sousa AR, Montuschi P, Fowler SJ, Sterk PJ; U-BIOPRED Study Group. Identification and prospective stability of electronic nose (eNose)-derived inflammatory phenotypes in patients with severe asthma. J Allergy Clin Immunol. 2018 Dec 6. pii: S0091- 6749(18)31722-6. doi: 10.1016/j.jaci.2018.10.058. PubMed PMID: 30529449.
44. Simpson AJ, Hekking PP, Shaw DE, Fleming LJ, Roberts G, Riley JH, Bates S, Sousa AR, Bansal AT, Pandis I, Sun K, Bakke PS, Caruso M, Dahlén B, Dahlén SE, Horvath I, Krug N, Montuschi P, Sandstrom T, Singer F, Adcock IM, Wagers SS, Djukanovic R, Chung KF, Sterk PJ, Fowler SJ; U-BIOPRED Study Group. Treatable traits in the European U-BIOPRED adult asthma cohorts. Allergy. 2018 Oct 11. doi: 10.1111/all.13629. [Epub ahead of print] PubMed PMID: 30307629.
45.Emma R, Bansal AT, Kolmert J, Wheelock CE, Dahlen SE, Loza MJ, De Meulder B, Lefaudeux D, Auffray C, Dahlen B, Bakke PS, Chanez P, Fowler SJ, Horvath I, Montuschi P, Krug N, Sanak M, Sandstrom T, Shaw DE, Fleming LJ, Djukanovic R, Howarth PH, Singer F, Sousa AR, Sterk PJ, Corfield J, Pandis I, Chung KF, Adcock IM, Lutter R, Fabbella L, Caruso M*; U-BIOPRED Study Group. Enhanced oxidative stress in smoking and ex-smoking severe asthma in the U-BIOPRED cohort. PLoS One. 2018 Sep 21;13(9):e0203874. doi: 10.1371/journal.pone.0203874. eCollection 2018. PubMed PMID: 30240401.
46. Brandsma J, Goss VM, Yang X, Bakke PS, Caruso M, Chanez P, Dahlén SE, Fowler SJ, Horvath I, Krug N, Montuschi P, Sanak M, Sandström T, Shaw DE, Chung KF, Singer F, Fleming LJ, Sousa AR, Pandis I, Bansal AT, Sterk PJ, Djukanović R, Postle AD; U-BIOPRED Study Group. Lipid phenotyping of lung epithelial lining fluid in healthy human volunteers. Metabolomics. 2018 Sep 17;14(10):123. doi:10.1007/s11306-018-1412-2.
47. Polosa R, Morjaria JB, Prosperini U, Russo C, Pennisi A, Puleo R, Caruso M, Caponnetto P. Health effects in COPD smokers who switch to electronic cigarettes: a retrospective-prospective 3-year follow-up. Int J Chron Obstruct Pulmon Dis. 2018 Aug 22;13:2533-2542. doi: 10.2147/COPD.S161138. eCollection 2018. PubMed PMID: 30197510; PubMed Central PMCID: PMC6113943.
48. Caruso M, Li Volti G, Furneri PM, Fuochi V, Emma R, Polosa R. Inflammatory and Oxidative Responses Induced by Exposure to Commonly Used e-Cigarette Flavoring Chemicals and Flavored e-Liquids without Nicotine. Frontiers in Physiology. 2018 Sep 13;9:1240. doi: 10.3389/fphys.2018.01240. eCollection 2018. PubMed PMID: 30271350; PubMed Central PMCID: PMC6147174.
49.Caruso M*, Emma R, Fuochi V, Furneri PM, Polosa R. Electronic cigarette vapour enhances pneumococcal adherence to airway epithelial cells under abnormal conditions of exposure. Eur Respir J. 2018 Sep 6;52(3). pii: 1800915. doi:10.1183/13993003.00915-2018. Print 2018 Sep. PubMed PMID: 30190260.
50. Caruso M*, Cibella F, Emma R, Campagna D, Tringali G, Amaradio MD, Polosa R. Basophil biomarkers as useful predictors for sublingual immunotherapy in allergic rhinitis. Int. Immunopharmacol. 2018 Jul; 60:50-58. doi: 10.1016/j.intimp.2018.04.034. Epub 2018 Apr 25. PubMed PMID: 29702283.
51.Burg D, Schofield JPR, Brandsma J, Staykova D, Folisi C, Bansal A, Nicholas B, Xian Y, Rowe A, Corfield J, Wilson S, Ward J, Lutter R, Fleming L, Shaw DE, Bakke PS, Caruso M, Dahlen SE, Fowler SJ, Hashimoto S, Horváth I, Howarth P, Krug N, Montuschi P, Sanak M, Sandström T, Singer F, Sun K, Pandis I, Auffray C, Sousa AR, Adcock IM, Chung KF, Sterk PJ, Djukanović R, Skipp PJ, The U-Biopred Study Group. Large-Scale Label-Free Quantitative Mapping of the Sputum Proteome. J Proteome Res. 2018 Jun 1;17(6):2072-2091. doi: 10.1021/acs.jproteome.8b00018. Epub 2018 May 23. PubMed PMID: 29737851.
52. Jevnikar Z, Östling J, Ax E, Calvén J, Thörn K, Israelsson E, Öberg L, Singhania A, Lau LCK, Wilson SJ, Ward JA, Chauhan A, Sousa AR, De Meulder B, Loza MJ, Baribaud F, Sterk PJ, Chung KF, Sun K, Guo Y, Adcock IM, Payne D, Dahlen B, Chanez P, Shaw DE, Krug N, Hohlfeld JM, Sandström T, Djukanovic R, James A, Hinks TSC, Howarth PH, Vaarala O, van Geest M, Olsson H; Unbiased Biomarkers in Prediction of Respiratory Disease Outcomes study group. Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation. J Allergy Clin Immunol. 2019 Feb;143(2):577-590. doi:10.1016/j.jaci.2018.05.026. Epub 2018 Jun 11. PubMed PMID: 29902480.
53. Morjaria JB§, Caruso M§, Emma R, Russo C, Polosa R. Treatment of Allergic Rhinitis as a Strategy for Preventing Asthma. Curr Allergy Asthma Rep. 2018 Mar 24;18(4):23. doi: 10.1007/s11882-018-0781-y. PubMed PMID: 29574527
54. Takahashi K, Pavlidis S, Ng Kee Kwong F, Hoda U, Rossios C, Sun K, Loza M, Baribaud F, Chanez P, Fowler SJ, Horvath I, Montuschi P, Singer F, Musial J, Dahlen B, Dahlen SE, Krug N, Sandstrom T, Shaw DE, Lutter R, Bakke P, Fleming LJ, Howarth PH, Caruso M, Sousa AR, Corfield J, Auffray C, De Meulder B, Lefaudeux D, Djukanovic R, Sterk PJ, Guo Y, Adcock IM, Chung KF; on behalf of the U-BIOPRED study group. Sputum proteomics and airway cell transcripts of current and ex-smokers with severe asthma in U-BIOPRED: an exploratory analysis. Eur Respir J. 2018 May 3;51(5). pii: 1702173. doi: 10.1183/13993003.02173-2017. Print 2018 May. PubMed PMID: 29650557.
55.Russo C, Cibella F, Mondati E, Caponnetto P, Frazzetto E, Caruso M, Caci G, Polosa R. Lack of Substantial Post-Cessation Weight Increase in Electronic Cigarettes Users. Int J Environ Res Public Health. 2018 Mar 23;15(4). pii: E581. doi: 10.3390/ijerph15040581. PubMed PMID: 29570695; PubMed Central PMCID:PMC5923623.
56. Li Volti G, Polosa R, Caruso M*. Assessment of E-cigarette impact on smokers: the importance of experimental conditions relevant to human consumption. Proc Natl Acad Sci USA. 2018 Apr 3;115(14):E3073-E3074. doi:10.1073/pnas.1801967115. PubMed PMID: 29535226; PubMed Central PMCID: PMC5889678.
57. Caruso M, Morjaria J, Emma R, Amaradio MD, Polosa R. Biologic agents for severe asthma patients: clinical perspectives and implications. Intern Emerg Med. 2018 Mar;13(2):155-176. doi: 10.1007/s11739- 017-1773-y. PubMed PMID: 29238905.
58. Di Mauro MD, Tomasello B, Giardina RC, Dattilo S, Mazzei V, Sinatra F, Caruso M, D'Antona N, Renis M. Sugar and mineral enriched fraction from olive mill wastewater for promising cosmeceutical application: characterization, in vitro and in vivo studies. Food Funct. 2017 Dec 13;8(12):4713-4722. doi:10.1039/c7fo01363a. PubMed PMID: 29165474.
59.Caruso M, Polosa R. Perplexing Conclusions Concerning Heat-Not-Burn Tobacco Cigarettes. JAMA Intern Med. 2017 Nov 1;177(11):1699. doi: 10.1001/jamainternmed.2017.5843. PubMed PMID: 29114793.
60.Takahashi K, Pavlidis S, Kwong FNK, Hoda U, Rossios C, Sun K, Loza MJ, Baribaud F, Chanez P, Fowler SJ, Horvath I, Montuschi P, Singer F, Sanak M, Dahlen B, Krug N, Sandström T, Shaw D, Lutter R, Fleming L, Howarth P, Caruso M, Sousa AR, Corfield J, Auffray C, De Meulder B, Lefaudeux D, Djukanovic R, Sterk PJ, Guo Y, Adcock IM, Chung KF. Sputum proteomics and airway cell transcripts of current and ex-smokers with severe asthma in U-BIOPRED: an exploratory analysis. Eur Respir J. 2018 May 3;51(5). pii: 1702173. doi: 10.1183/13993003.02173-2017.
61. M. Caruso, R. Emma, P. Brinkman, P.J. Sterk, A.T. Bansal, B. De Meulder, D. Lefaudeux, C. Auffray, S.J. Fowler, N.J.W. Rattray, G. Pennazza, P. Bakke, P. Chanez, I. Horvath, N. Krug, P. Montuschi, M. Sanak, T. Sandström, D. Shaw, K.F. Chung, R. Djukanovic, F. Singer, A.R. Sousa, S.E. Dahlén, J. Kolmert, H. Weda, A. Vink, H. Knobel. Volatile Organic Compounds Breathprinting of U-BIOPRED Severe Asthma smokers/ex-smokers cohort. Eur Respir J. September 2017. Doi:10.1183/1393003.congress-2017.PA2018. Conference: ERS 2017.
62. Craig E Wheelock, Shama Naz, Stacey Reinke, Romanas Chaleckis, James Schofield, Paul Skipp, Jeanette Bigler, Matthew J Loza, Fred Baribaud, Per Bakke, Massimo Caruso, Pascal Chanez, Stephen J Fowler, Kiss Horvath, Norbert Krug, Paolo Montuschi, Marek Sanak, Thomas Sandström, Dominick Shaw, Fan Chung, Ratko Djukanovic, Florian Singer, Ana Sousa, Ioannis Pandis, Aruna T Bansal, Peter Sterk, Sven- Erik Dalhén. Urinary metabolomics-based molecular sub-phenotyping of the U-BIOPRED asthma cohort. Eur Respir J. September 2017 Doi:10.1183/1393003.congress-2017.PA4939. Conference: ERS International Congress 2017 abstracts.
63.Hekking PP, Loza MJ, Pavlidis S, de Meulder B, Lefaudeux D, Baribaud F, Auffray C, Wagener AH, Brinkman P Ir, Lutter R Ir, Bansal AT, Sousa AR, Bates SA, Pandis Y, Fleming LJ, Shaw DE, Fowler SJ, Guo Y, Meiser A, Sun K, Corfield J, Howarth PH, Bel EH, Adcock IM, Chung KF, Djukanovic R, Sterk PJ; U-BIOPRED Study Group. Pathway discovery using transcriptomic profiles in adult-onset severe asthma. J Allergy Clin Immunol. 2018 Apr;141(4):1280-1290. doi:10.1016/j.jaci.2017.06.037. PubMed PMID: 28756296.
64. Dominick E. Shaw, Ana R. Sousa, Stephen J. Fowler, Louise J. Fleming, Graham Roberts, Julie Corfield, Ioannis Pandis, Aruna T. Bansal, Elisabeth H. Bel, Charles Auffray, Chris H. Compton, Hans Bisgaard, Enrica Bucchioni, Massimo Caruso, Pascal Chanez, Barbro Dahlén, Sven-Erik Dahlen, Kerry Dyson, Urs Frey, Thomas Geiser, Maria Gerhardsson de Verdier, David Gibeon, Yi-ke Guo, Simone Hashimoto, Gunilla Hedlin, Elizabeth Jeyasingham, Pieter-Paul W. Hekking, Tim Higenbottam, Ildikó Horváth, Alan J. Knox, Norbert Krug, Veit J. Erpenbeck, Lars X. Larsson, Nikos Lazarinis, John G. Matthews, Roelinde Middelveld, Paolo Montuschi, Jacek Musial, David Myles, Laurie Pahus, Thomas Sandström, Wolfgang Seibold, Florian Singer, Karin Strandberg, Jorgen Vestbo, Nadja Vissing, Christophe von Garnier, Ian M. Adcock, Scott Wagers, Anthony Rowe, Peter Howarth, Ariane H. Wagener, Ratko Djukanovic, Peter J. Sterk and Kian Fan Chung on behalf of the U-BIOPRED Study Group. Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort. Eur Respir J 2015; 46: 1308- 1321. Eur Respir J. 2017 Jun 22;49(6). pii: 1550779. doi: 10.1183/13993003.50779-2015. Print 2017 Jun. PubMed PMID: 28642304.
65.Loza MJ, Djukanovic R, Chung KF, et al. ADEPT (Airways Disease Endotyping for Personalized Therapeutics) and U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Disease Outcome Consortium) investigators.; Validated and longitudinally stable asthma phenotypes based on cluster analysis of the ADEPT study. Respir Res. 2016 Dec 15;17(1):165. PubMed PMID: 27978840.
66. Lefaudeux D, De Meulder B, Loza MJ, Peffer N, Rowe A, Baribaud F, Bansal AT, Lutter R, Sousa AR, Corfield J, Pandis I, Bakke PS, Caruso M, Chanez P, Dahlén SE, Fleming LJ, Fowler SJ, Horvath I, Krug N, Montuschi P, Sanak M, Sandstrom T, Shaw DE, Singer F, Sterk PJ, Roberts G, Adcock IM, Djukanovic R, Auffray C, Chung KF; U-BIOPRED Study Group. U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics. J Allergy Clin Immunol. 2017;139(6):1797–1807. doi:10.1016/j.jaci.2016.08.048 PubMed PMID: 27773852.
67. Cibella F, Campagna D, Caponnetto P, Amaradio MD, Caruso M, Russo C, Cockcroft DW, Polosa R. Lung function and respiratory symptoms in a randomized smoking cessation trial of electronic cigarettes. Clin Sci (Lond). 2016 Nov 1;130(21):1929-37. doi: 10.1042/CS20160268. PubMed PMID:27543458.
68. Emma R, Caruso M, Polosa R. Smoking history can influence the epigenetic and gene expression profile. Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L525. doi: 10.1152/ajplung.00285.2016. PubMed PMID: 27507815.
69. Campagna D, Cibella F, Caponnetto P, Amaradio MD, Caruso M, Morjaria JB, Malerba M, Polosa R. Changes in breathomics from a 1-year randomized smoking cessation trial of electronic cigarettes. Eur J Clin Invest. 2016 Jun 20. doi: 10.1111/eci.12651.
70.Polosa R, Morjaria JB, Caponnetto P, Caruso M, Campagna D, Amaradio MD, Ciampi G, Russo C, Fisichella A. Persisting long-term benefits of smoking abstinence and reduction in asthmatic smokers who have switched to electronic cigarettes. Discov Med. 2016 Feb;21(114):99-108.
71. Russo C, Cibella F, Caponnetto P, Campagna D, Maglia M, Frazzetto E, Mondati E, Caruso M, Polosa R. Evaluation of Post Cessation Weight Gain in a 1-Year Randomized Smoking Cessation Trial of Electronic Cigarettes. Sci Rep. 2016 Jan 5;6:18763. doi: 10.1038/srep18763. PubMed PMID: 26729619; PubMed Central PMCID: PMC4700433.
72. K Farsalinos, F Cibella, P Caponnetto, D Campagna, JB Morjaria, E Battaglia, M Caruso, C Russo, R Polosa. Effect of continuous smoking reduction and abstinence on blood pressure and heart rate in smokers switching to electronic cigarettes. Intern Emerg Med. 2016 Feb;11(1):85-94. doi: 10.1007/s11739-015- 1361-y. PubMed PMID: 26749533.
73. Polosa R, Caruso M, Guarino F. Comments on Scheffler et al. Cytotoxic Evaluation of E-Liquid Aerosol using Different Lung Derived Cell Models. Int J Environ Res Public Health. 2016 Jan 6;13(1). pii: E108. doi: 10.3390/ijerph13010108. PubMed PMID: 26751462; PubMed Central PMCID: PMC4730499.
74. Marino E, Caruso M, Campagna D, Polosa R. Impact of air quality on lung health: myth or reality? Ther Adv Chronic Dis. 2015 Sep;6(5):286-98. doi: 10.1177/2040622315587256. Review. PubMed PMID: 26336597; PubMed Central PMCID: PMC4549691.
75. Polosa R, Caruso M, Caponnetto P. Acrolein levels in e-cigarettes - Letter. Cancer Prev Res (Phila). 2015 Nov 10. PubMed PMID: 26554633.
76. Shaw DE, Sousa AR, Fowler SJ, Fleming LJ, Roberts G, Corfield J, Pandis I, Bansal AT, Bel EH, Auffray C, Compton CH, Bisgaard H, Bucchioni E, Caruso M, et al.; Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort. U-BIOPRED Study Group. Eur Respir J. 2015 Nov;46(5):1308-21. doi: 10.1183/13993003.00779-2015.
77. Bonaventura G, Chamayou S, Liprino A, Guglielmino A, Fichera M, Caruso M, Barcellona ML. Different Tissue-Derived Stem Cells: A Comparison of Neural Differentiation Capability. PLoS One. 2015 Oct 30;10(10):e0140790. doi:10.1371/journal.pone.0140790. eCollection 2015.
78.Polosa R, Bellinvia S, Caruso M, Emma R, Alamo A, Kowalski ML, Domingo C. Weekly low-dose methotrexate for reduction of Global Initiative for Asthma Step 5 treatment in severe refractory asthma: study protocol for a randomized controlled trial. Trials. 2014 Dec 18;15:492. doi: 10.1186/1745-6215-15- 492.
79.Luca T, Barresi V, Privitera G, Musso N, Caruso M, Condorelli DF, Castorina S. In vitro combined treatment with cetuximab and trastuzumab inhibits growth of colon cancer cells. Cell Prolif. 2014 Oct;47(5):435-447.
80.Polosa R, Morjaria J, Caponnetto P, Caruso M, Strano S, Battaglia E, Russo C. Effect of smoking abstinence and reduction in asthmatic smokers switching to electronic cigarettes: evidence for harm reversal. Int J Environ Res Public Health. 2014 May 8;11(5):4965-77. doi: 10.3390/ijerph110504965.
81. Morjaria JB, Caruso M, Rosalia E, Russo C, Polosa R. Preventing progression of allergic rhinitis to asthma. Curr Allergy Asthma Rep. 2014 Feb;14(2):412. doi:10.1007/s11882-013-0412-6. Review. PubMed PMID: 24408536.
82. Polosa R, Caruso M, Oliveri Conti G, Ferrante M. Air Pollution: focus on lung health. Intern Emerg Med (2013) 8 (Suppl): S47–S54.
83. Caruso M, Crisafulli E, Lizzio R, Polosa R. Biologic therapy for atopic asthma and beyond. Curr Opin Allergy Clin Immunol. 2013 Dec;13(6):677-85.
84. Caponnetto P, Campagna D, Cibella F, Morjaria JB, Caruso M, Russo C, Polosa R. EffiCiency and Safety of an eLectronic cigAreTte (ECLAT) as Tobacco Cigarettes Substitute: A Prospective 12-Month Randomized Control Design Study. PLoS One. 2013 Jun 24;8(6):e66317
85. Spicuzza L, Scuderi V, Morjaria JB, Prosperini G, Arcidiacono G, Caruso M, Folisi C, Di Maria GU, Polosa R. Airway responsiveness to adenosine after a single dose of fluticasone propionate discriminates asthma from COPD. Pulm Pharmacol Ther. 2013 May 18.
86. Caruso M*, Alamo A, Crisafulli E, Raciti C, Fisichella A, Polosa R. Adenosine signaling pathways as potential therapeutic targets in respiratory disease. Expert Opin Ther Targets. 2013 May 4.
87.Caruso M*, Crisafulli E, Demma S, Holgate S, Polosa R. Disabling inflammatory pathways with biologics and resulting clinical outcomes in severe asthma. Expert Opin Biol Ther. 2013 Mar;13(3):393- 402.
88. Guarino F, Cantarella G, Caruso M, Russo C, Mancuso S, Arcidiacono G, Cacciola RR, Bernardini R, Polosa R. Endothelial activation and injury by cigarette smoke exposure. J Biol Regul Homeost Agents. 2011 Apr-Jun;25(2):259.
89. Li Volti G, Galvano F, Frigiola A, Guccione S, Di Giacomo C, Forte S, Tringali G, Caruso M, Adekoya OA, Gazzolo D. Potential immunoregulatory role of heme oxygenase-1 in human milk: a combined biochemical and molecular modeling approach. J Nutr Biochem. 2010 Sep;21(9):865-71.
90.Caruso M, Varani K, Tringali G, Polosa R. Adenosine and adenosine receptors: their contribution to airway inflammation and therapeutic potential in asthma. Curr Med Chem. 2009;16(29):3875-85. Review. PubMed PMID: 19747135.
91. Caruso M, Frasca G, Di Giuseppe PLM, Pennisi A, Tringali G, Bonina FP. Effects of a new nutraceutical ingredient on allergen-induced sulphidoleukotrienes production and CD63 expression in allergic subjects. International Immunopharmacology. 2008 Dec 20;8(13-14):1781-6.
92. Li Volti G, Sorrenti V, Acquaviva R, Murabito P, Gullo A, Barcellona ML, Galvano F, Rodella L, Rezzani R, Vanella L, Tringali G, Caruso M, Gazzolo D, Di Giacomo C. Effect of ischemia/reperfusion on renal expression and activity of NG-NG-dimethylarginine dimethylaminohydrolases. Anesthesiology. 2008 Dec;109(6):1054-62.
93.Caruso M, Tringali G, Di Giuseppe PLM, Pennisi AR, Roccaro G, Polosa R. Diagnoses of adverse drug reactions by flow cytometry basophils degranulation test vs basophils activation test. Proceedings of the XXV National Conference of the Italian Society GIC. Cytometry (Part A). 2007 Dec. 73A (1); 48–108.
94. Caruso M, Tringali G, Polosa R. Evidence for A Functional Contribution of Adenosine Signalling in Inflammatory Airway Diseases. Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry. 2007 August, Volume 7, No. 4. pp. 286-297.
95.Caruso M, Holgate ST, Polosa R. Adenosine signalling in airways. Curr Opin Pharmacol. 2006 Jun;6(3):251-6. Epub 2006 Apr 3.
96.C Di Pietro, S Piro, G Tabbì, M Ragusa,V Di Pietro, V Zimmitti, M Anello, U Consoli, E Trovato Salinaro, M Caruso, C Vancheri, N Crimi, MG Sabini, GAP Cirrone, L Raffaele, G Privitera, A Pulvirenti, R Giugno, A Ferro, G Cuttone, S Lo Nigro, R Purrello, F Purrello, M Purrello. Cellular and Molecular Effects Of Protons: Apoptosis Induction And Potential Implications For Cancer Therapy. Apoptosis. 2006 Jan;11(1):57-66.
97. Vancheri C, Gili E, Mastruzzo C, Trovato Salinaro E, LoFurno D, Pistorio MP, Caruso M, La Rosa C, Failla M, Crimi N. Bradykinin differentiates human lung fibroblasts to a myofibroblast phenotype via the B2 receptor. J Allergy Clin Immunol. 2005 Dec;116(6):1242-8.
98. Vancheri C, Mastruzzo C, Trovato-Salinaro E, Gili E, Lo Furno D, Pistorio MP, Caruso M, La Rosa C, Crimi C, Failla M, Crimi N. Interaction between human lung fibroblasts and T-lymphocytes prevents activation of CD4+ cells. Respir Res. 2005 Sep 13;6:103.
99. Calafiore M., Battaglia G., Zappalà A., Trovato-Salinaro E., Caraci F., Caruso M., Vancheri C., Sortino M.A., Nicoletti F., and Copani A. Progenitor cells form the adult mouse brain acquire a neuronal phenotype in response to ß-amyloid. Neurobiol Aging. 2006 Apr; 27(4):606-13.
100. Sortino M.A., Chiari M., Vancheri C., Caruso M., Nicoletti F., Canonico P.L., Copani A. Glia Mediates the Neuroprotective Action of Estradiol on beta-Amiloid-Induced Neuronal Death. Endocrinology 2004 Nov; 145(11): 5080-6.

SCIENTIFIC CONGRESSES
1. Speaker: In Vitro mutagenicity potential of a Pod-Based E-Cigarette Aerosol Compared to Cigarette Smoke: the REPLICA PROJECT. Caruso M. RESEARCH TRACK SESSION IV. “5th Scientific Summit on Tobacco Harm Reduction: Novel Products, Research & Policy”. 21-22 September, 2022.
2. Speaker: Comparative assessment of electronic nicotine delivery systems aerosol and cigarette smoke on endothelial cell migration: the REPLICA PROJECT. Caruso M. RESEARCH TRACK SESSION IV. “5th Scientific Summit on Tobacco Harm Reduction: Novel Products, Research & Policy”. 21-22 September, 2022.
3. Invited speaker: Electronic nicotine delivery systems exhibit lower toxicity compared to cigarettes. the “REPLICA STUDY GROUP” experience. Caruso M. Thematic category: Toxicology and aerosol chemistry. “4th Scientific Summit on Tobacco Harm Reduction: Novel Products, Research & Policy”. 29-30 Settembre, 2021.
4. Oral communication: What is the best approach to assess the vapor-induced cytotoxicity of ENDS? A road map to the destination. Caruso M. Cooperation Centre for Scientific Research Relative to Tobacco (CORESTA) “Smoke-Techno Conference 2021” (Virtual Conference). 18 - 28 Ottobre, 2021
5. Replica Project - Interview: G. Li Volti and M. Caruso - 8th Global Forum on Nicotine 2021 (GFN 2021); Liverpool, 17-18 June 2021 - GFN Fives - Science and innovation section
6. Oral communication: Electronic cigarette liquids inhibit pathogenic bacteria growth in vitro. 6th Global Forum on Nicotine. 17-20 June 2019. Warsaw.
7. Oral communication: Safety and Efficacy Of Subcutaneous Pollen Immunotherapy Administered By Needleless Device In Allergic Rhinitis Adults. Annual Congress of European Academy of Allergy and Clinical Immunology (EAACI). Munich. May 2018.
8. Invited Speaker: Test di attivazione in vitro nel laboratorio di allergologia. 14° Congresso Regionale SiBioc - Sezione Sicilia. "Innovazione in Medicina di Laboratorio". Cefalù - 6 Ottobre 2017
9. Invited Speaker: Nuovi sviluppi in Immunoterapia senza ago. Evento: Meeting scientifico: “La grande sfida”. Sponsorizzato da Bial Aristegui Italia. ROMA 06 Ottobre 2016 - MILANO 07 Ottobre 2016.
10.Oral communication: Could Basophil Activation Tests (BATs) have a role in diagnosis of Food Allergies? 10th EuroBAT Meeting - The European Consortium on Application of Flow Cytometry in Allergy; Session: Food Allergy. Rome (Italy) - 12 October 2016
11. Chair: Miscellaneous drug allergy Poster Session - Annual Congress of European Academy of Allergy and Clinical Immunology (EAACI). Barcellona (Spagna) – 8 Giugno 2015
12.Oral communication: Anaphilaxis to Local Anaesthetics: an integrated approach clinical-laboratory. Congress of EAACI 2015 (European Academy of Allergy and Clinical Immunology). Barcelona (Spain) 6-10 June 2015.
13. Oral communication: Investigating the Delayed Adverse Reactions to Non-Steroidal Anti-Inflammatory Drugs by an ex-vivo Stimulation Test. A new safety approach to support the drug allergy diagnosis. Collegium Internationale Allergologicum in Petersberg, Germany, 13-18 September 2014
14. Oral communication: Usefulness of basophil activation markers in the diagnosis of drug hypersensitive reaction to amoxicillin. 8th EuroBAT Meeting - The European Consortium on Application of Flow Cytometry in Allergy. Session: Drugs allergy/mixed topics - Munich, Germany. 12/13 December 2014
15.Invited Speaker: Orticaria cronica autoimmune: un approccio citofluorimetrico come supporto alla diagnosi ed all'inquadramento clinico e terapeutico. Relazione su invito. 10° Congresso Regionale SiBioc - Sezione Sicilia. "Dalla Ricerca Biomedica Alla Medicina Di Laboratorio". Caltanissetta - 25 Settembre 2013
16. Oral communication: Evaluation of drug hypersensitivity: The clinical laboratory as valuable help to make a correct diagnosis. Caruso M – 42° National Congress of Italian Society of Clinical Biochemistry and Molecular Biology (SIBioC) – Rome. 5–8 October 2010.
17.Invited Speaker: Flow2- CAST - Test di citometria a flusso nella diagnosi di allergie. Caruso M. Congresso Nazionale AIPaCMeM (Associazione Italiana di Patologia Clinica e Medicina Molecolare) - Tivoli (Roma) – 12-15 maggio 2009
18. Oral communication: Le lipoproteine a bassa densità ossidate stimolano la migrazione e l’attivazione degli eosinofili. Caruso M, Mastruzzo C, Lupo G, La Rosa C, Pistorio MP, Anfuso CD, Gili E, Trovato Salinaro E, Crimi N, Alberghina M, Vancheri C. Atti del 3° Congresso Nazionale S.I.Ci.C.S. – Palermo, 13-15 Aprile 2005.

SCIENTIFIC SEMINARS
1. The “REPLICA” project: addressing the replication crisis in tobacco harm reduction studies. Center for Biotechnology/Sbarro Institute. Temple University. Hosts: Dr. A. Giordano, Dr. A. Sun. May 2, 2023.
2. The “Replica Study Group” experience: working, harmonizing, facing challenges and growing all together. Center for Biotechnology/Sbarro Institute. Temple University. Philadelphia (USA). Hosts: Dr. A. Giordano, Dr. A. Sun. April 5, 2022.
3. The “REPLICA” project. Towards the standardization and harmonization of experimental protocols in an international consortium. College of Medicine and Health Sciences, Department of Clinical Biochemistry, Sultan Qaboos University. Khodh (Oman). Host: Dr. F. Zadijali. February 24, 2020.
4. The “REPLICA” project. Towards the standardization and harmonization of experimental protocols in an international consortium Department of Microbiology and Immunology, Faculty of Medical Sciences, University of Kragujevac (Serbia). Host: Dr. V. Volarevic. February 22, 2020.
5. The “REPLICA” project. Towards the standardization and harmonization of experimental protocols in an international consortium. Department of Pharmacy, University of Patras, Patras (Greece). Host: Dr. K. Poulas. February 18, 2020.
6. “Flow cytometry applied to the clinical laboratory: from hematology to allergology”. School of Medicine. University of Catania. June 14, 2017
7. “Technical applications of the flow cytometry in the clinical and research laboratory”. Master course in Biology. University of Catania, Department of Biology. May 15, 2017.

BOOKS
Eziopatogenesi e diagnostica delle farmaco-reattività (Aetiopathogenesis and diagnostics of drug- reactivity). G. Tringali, C. De Francisci, G Pennisi, M. Caruso. Bonanno Editore, 2006. Italy.