GRASSO GIUSEPPE

Professore Associato

Orari di ricevimento

Giovedì previo appuntamento

Curriculum

EDUCATION
2016 National Scientific Qualification for becoming a Full Professor in “Chemical Sciences and Inorganic Systems” (03/B1) and “Chemical Fundaments in Technology” (03/B2) and Associate Professor in “Analytical Chemistry” (03/A1)
2004 Qualified for the chemist register
2000 - 2003 PhD in Physical Chemistry (Subject: Solid State NMR on Polymers).
University of Nottingham (UK) – Chemistry Department
Thesis: “Solid-State NMR studies of Alkali Fullerides and long-chain Alkanes”.
1995 - 2000 Laurea in Chemistry (Specializing in Chemistry of Materials)
Università degli studi di Catania
Thesis: "Devise Organic Molecules on Silicon Surface"
Grade: 110/110 cum laude
1990 - 1995 Diploma of Maturità Scientifica
Liceo Scientifico “Galileo Galilei” - Catania
Grade: 60/60

ACADEMIC POSITIONS AND ACTIVITIES
2023 President of the commission for the selection of an RTD-A position (CHIM/03) call DR REP. N. 1131/2023 del 07 December 2022 CODE PICA - 22RTDA006
11/2020 – today Università di Catania  President of the degree course “Chemistry”
09/2018 – today Università di Catania  Position: Associate Professor in General and Inorganic Chemistry.
11/2010 – 08/2018 Università di Catania  Position: permanent position as Researcher in General and Inorganic Chemistry.
09/2007 – 08/2010 Università di Catania  Position: research associate. International FIRB project RBIN04L28Y: “Environmental factors in Alzheimer and type 2 diabetes diseases”.
06/2007 – 08/2007 Istituto Nazionale Biostrutture e Biosistemi  Position: research associate. Project: “EURAMY: Systemic Amyloidoses in Europe”.
03/2007 – 05/2007 Consiglio Nazionale delle Ricerche  Position: expert in “Synthesis and characterization of new bio conjugate with antifibrillogenic activity”.
01/2007 - 02/2007 Università di Catania  Position: research associate in the COFIN 2005 project entitled “Detection of the hybridation of peptide nucleic acids (PNAs) by surface plasmon resonance imaging and array technology”.
2004 - 2006 Università di Catania  Position: research associate of C.I.R.C.M.S.B. for the strategic project F.I.R.B. “POST GENOMICA” about synthesis and characterization of molecules as new MMP inhibitors.
2003 - 2004 University of Nottingham  Position: research associate, grant GR/N02023: “An investigation of semi-crystallinity in polymers using labelled and star-branched long Alkanes”.
2000 - 2002 University of Nottingham  Position: Lab Demonstrator


TEACHING AND INVITED LECTURES
• Member of the PhD school of Chemistry of Catania (2021-today)
• “Invited Lecture” at “Université de Bretagne Occidentale”, Brest, France, 5-10 July 2022.
• “Invited Lectures” within the ERASMUS staff mobility program: “Mass Spectrometry: a short course” Paris, France, University of Cergy Pointoise, 12-17 July 2022.
• “Invited Professor” University of Cergy Pointoise, Paris, 23rd May-19th June 2021.
• “Invited Lectures” within the ERASMUS staff mobility program: “Protein aggregation: explaining conformational disorders” Paris, France, 8th-13th of March 2020.
• “Invited Lecture” within the ERASMUS staff mobility program: "A bioinorganic perspective on Alzheimer’s disease: theoretical background and experimental methods" Krakow, Poland 22nd-27th of May 2017.
• “Invited Lecture” at workshop: "Biomolecules: Identification and Function" Krakow, Poland, 21st-22nd of October 2016.
• “Invited Lecture” at “Baylor College Of Medicine”, Houston, USA, 23th of May 2016, within the Fulbright Outreach Lecture Funding program.
• “Invited Lecture” at “Leiden Institute of Chemistry, Leiden University”, Leiden, The Netherlands, 29th of May 2015.
• Teacher of PhD students of the course: “ A bioinorganic approach to neurodegenerative diseases”, Academic Year: 2013-2014 and 2014-2015.
• Teacher of “Foundations and Teaching of Chemistry”, Course PAS CLASS A 059, Academic Year: 2013-2014 and 2014-2015, at ’University of Catania.
• “Invited Lecture” at “Université de Bretagne Occidentale”, Brest, France, May 15th 2014.
• Teacher of “Microdestructive techniques and laser desorption techniques”, 20 hours at the Course for “Expert Researchers in the monitoring and diagnostic of cultural heritage”, Project IT@CHA FORMAZIONE, “Tecnologie Italiane per applicazioni avanzate nei beni culturali”, PON01_00625, Lecce, 14-16 April 2014.
• Teacher at Master school “Progettazione e Diagnostica Molecolare in oncologia” Department of Chemical Sciences of the University of Catania (2012-2013) Modules: A.2.4 – Spectroscopy for Molecular diagnosis 2 (10 hours); A.3.6- Metal complexes as antitumoral drugs and their targets (20 hours).
• General and Inorganic Chemistry I and Laboratory (6 CFU), Corso di Laurea in Chemistry University of Catania since 2019 until now.
• General and Inorganic Chemistry (9 CFU), Corso di Laurea in Biological Sciences, University of Catania since 2012 until now
• General Chemistry (6 CFU), Corso di Laurea in Scienze e Tecnologie Alimentari, at “Facoltà di Agraria” of University of Catania (2011-2012)
• Bioinorganic Chemistry (6 CFU), Corso di Laurea in Chemistry (A.A. 2011-2012).
• Tutor of students at “Corso di laurea in Scienze e Tecnologie Alimentari”.
• Supervisor of many undergraduate and master students at the University of Catania since 2010.
• University of Nottingham-Lab Demonstrator, Lab of Physical Chemistry I. Nottingham 2000-2002
• “Invited Lecture” at “Summer School” entitled "PHYSICAL METHODS IN BIOINORGANIC CHEMISTRY" organized at Ioannina, Greece, 26 May – 2 June, 2008
• “Invited Lecture” at “Scuola Nazionale di Chimica Bioinorganica, Certosa di Pontignano, Siena, Italy, 3-6 July 2011
• Member of examination board for: Analytical Chemistry I, Instrumental Analytical Chemistry III, Inorganic Chemistry, Metallomics with Proteomics elements, General and Inorganic Chemistry

SCIENTIFIC COLLABORATIONS:
• IRCSS Bietti, Roma: coordinator of the signed agreement with the Department of Chemical Sciences, University of Catania (2022)
• Prof. M Coletta, Università degli Studi di Roma Tor Vergata (Italy)
• Prof. J J Titman, University of Nottingham (UK)
• Prof. J Silberring, AGH University of Science and Technology (Poland)
• Prof. M Fragai, Magnetic Resonance Center (CERM), Università di Firenze (Italy)
• Dott. G Malgieri, Dipartimento di Scienze Ambientali, Seconda Università di Napoli (Italy)
• Prof. S Bonnet, Faculty of Science, Leiden Institute of Chemistry, Metals in Catalysis, Biomimetics & Inorganic Materials (The Netherlands)
• Prof. Paul H. Axelsen, University of Pennsylvania, Philadelphia, PA, (USA)
• Prof. Anthony Memboeuf, Université De Bretagne Occidentale (France)
• Prof. Elisa Peroni University of CergyPointoise (France)

ERASMUS COORDINATOR
Erasmus+ Program, Key Action 1- Mobility for learners and staff-Higher Education Student and Staff Mobility with:
• UNIVERSITE DE BRETAGNE OCCIDENTALE (France)
• UNIVERSITE DE CERGY-PONTOISE (France)
• AKADEMIA GÓRNICZO-HUTNICZA (Poland)
• THE UNIVERSITY OF NOTTINGHAM (UK)
• MARTIN-LUTHER-UNIVERSITÄT HALLE-WITTENBERG (Germany)
• UNIVERSIDADE DE LISBOA (Portugal)

EDITOR AND REVIEWING ACTIVITY:
Reviewer PRIN projects
Reviewer CEA project (France)
Reviewer PhD Thesis (University of Florence)
Reviewer for the follower journals:
• ACS omega
• Advanced Sciences
• Analytical and Bioanalytical Chemistry
• Analytical Chemistry
• Angewandte Chemie International Edition
• Antioxidant
• Basic & Clinical Pharmacology & Toxicology
• BBA-Proteins and Proteomics
• Biometals
• Bioscience Reports
• ChemComm
• Chemical Science
• ChemMedChem
• Current Pharmaceutical Design
• Dalton Transactions
• Diagnostics
• Embo Journal
• European Journal of Mass Spectrometry
• Experimental Biology and Medicine
• FEBS open
• Food Chemistry
• Inorganica Chimica Acta
• International Journal of Mass Spectrometry
• International Journal of Molecular Sciences
• International Journal of Nanomedicine
• Journal of Alzheimer’s Disease
• Journal of Cellular Biochemistry
• Journal of Clinical Laboratory Analysis
• Journal of Inorganic Biochemistry
• Journal of Molecular Liquid
• Journal of Pharmaceutical Analyses
• Journal of Proteome Research
• Journal of Proteomics
• Journal of the American Society for Mass Spectrometry
• Mass Spectrometry Reviews
• Metabolites
• Metallomics
• Nature Communication
• Nature Protocols
• Neuropharmacology
• Oxidative Medicine and Cellular Longevity
• Pharmacological Reports
• Plos One
• Rapid Communications in Mass Spectrometry
• RSC Advances
• Talanta
• Tissue and Cells
• Traslational Neurodegeneration
Coauthor of the book: Fondamenti di chimica generale, Edises, (2022)
Editor of the book: Mass Spectrometry: An Applied Approach, 2nd Edition (2019)
Marek Smoluch (Editor), Giuseppe Grasso (Editor), Piotr Suder (Editor), Jerzy Silberring (Editor)
Guest Editor of Special Issue “Metallomics” in Metals EISSN 2075-4701
Author of the Novel: Immortalizer-La vita dalla Morte, Leonida Edizioni 2022, COD: 978-88-3374-166-6



LANGUAGES
Italian: Native speaker
English: Fluent

Research activity outside Italy:
Post-Doc, University of Nottingham (UK) 2004 (1 year)
Fulbright Visiting Professor, University of Pennsylvania, Philadelphia (USA) 2015-2016 (9 months)
Invited Professor, University of Cergy-Paris, Paris, France, 2021 (1 month)
Invited Professor, University of Cergy-Paris, Paris, France, 2023-2024 (10 months)

RESEARCH PROJECTS AND AWARDS:
• Principal Investigator PRIN 2023: “Molecular details on the early phase of amyloid beta peptides aggregation: a multilevel approach based on carbon dots fluorescence and diffusion coefficients measurements to unveil the pathogenic molecular mechanisms at the base of Alzheimer’s disease”.
• Departmental Coordinator: PO Salute T4 dal titolo “RIPOSIZONAMENTO DI FARMACI NELLE MALATTIE NEUROLOGICHE RARE DEL SISTEMA NERVOSO IN ETA’ PEDIATRICA”, 2023.
• Departmental Coordinator of project 3N-ORACLE, Piaceri 2020.
• Foreign Unit Coordinator, Project CES 07 Chimie moléculaire, chimie durable et procédés associés AAPG ANR 2018
• Principal Investigator PRIN 2015: “Role of metal dyshomeostasis and ubiquitin-proteasome system derangement in brain pathologies: risk factors and neuroprotective strategies”
• Winner of the selection for the “Fulbright Visiting Scholar Program” 2015/2016, to spend 9 months at the University of Pennsylvania, working on “Apolipoprotein E, metals and Alzheimer's Disease: uncovering underlying unifying mechanism to explain pathogenesis”
• Participant: FIR 2014 Stimuli responsive multifunctional graphene oxide nanoplatforms for drug delivery applications
• Participant: FIRB RINAME RBAP114AMK Rete Integrata per la nanomedicina
• Participant: PRIN 2010-2011 “Ioni Metallici nelle Patologie da Invecchiamento: Interplay tra Metallostasi e Proteostasi nella Neurodegenerazione”
• Participant: FIRB 2004 Internat. “Fattori ambientali nelle patologie di Alzheimer e Diabete di tipo 2”
• Participant: “EURAMY: Systemic Amyloidoses in Europe”
• Participant: FIRB 2003. “Folding e aggregazione di proteine: metalli e biomolecole nelle malattie conformazionali”
• Participant: PRA 2008. “Riconoscimento in sistemi supramolecolari e biomolecolari”
• Participant: PRA 2007. “Interazione di ioni metallici e loro composti con bio-molecole”
• Participant: PRA 2006. “Interazione di ioni metallici e loro composti con bio-molecole”
• Participant: PRA 2005. “Interazione di ioni metallici e loro composti con bio-molecole”
• Participant: COFIN 2005. “Rivelazione della ibridazione e peptide nucleic acids (PNAs) mediante surface plasmon resonance imaging e tecnologia ad array”
• Participant: PRIN 2008. “Omeostasi di Aβ: fattori di crescita neuronali, metalli di transizione ed agenti degradativi nella patologia di Alzheimer”
• Participant: Progetto strategico FIRB “POST GENOMICA” di progettazione e sintesi di nuove molecole quali inibitori delle Metallo-Proteasi di Matrice
• Participant: Progetto Strategico FIRB. “Elucidazione strutturale di bersagli proteici critici per malattie e studio delle basi molecolari della specificità dei candidati farmaci”
• Participant: PRIN 2006. "Ruolo dell'interazione dei metalli con il sistema ubiquitina/proteasoma nella patogenesi delle malattie conformazionali
• Participant: PON 01_01078 "IDENTIFICAZIONE DI BIOMARCATORI E SVILUPPO DI METODI DIAGNOSTICI E TERAPEUTICI NEL CAMPO DELL'ONCOLOGIA E DELLA BIOLOGIA VASCOLARE"
• Participant: PON02_00355_2964193 "HIPPOCRATES"

SCIENTIFIC ACTIVITY
The research of Prof. Grasso is focused on the study of molecular interactions between biomolecules involved in certain neurodegenerative diseases such as Alzheimer's disease. In particular, some metalloproteases involved with these diseases are studied and the possibility of modulating the enzymatic activity of these biomolecules for therapeutic purposes is investigated. The influence that metal ions such as copper or zinc and oxidative stress have on the biomolecular mechanisms involved in neurodegeneration is also studied using various analytical techniques such as mass spectrometry, surface plasmon resonance, NMR as well as biochemical methods.

ORCID: 0002-7179-4835
ResearcherID: E-3893-2010
Scopus Author ID: 56875852900
h-index: 29
Total Citations: 1748
Supervisor of 15 Bachelor and Master Students and 4 PhD Students

SCIENTIFIC PAPERS
(1) Adhesion properties on nanometric scale of silicon oxide and silicon nitride surfaces modified by 1-octadecene.
B. Pignataro, G. Grasso, L. Renna, G. Marletta
Surface and Interface Analysis (2002) 33(2), 54–58. (IF =1,15)
(2) Electronic structure of the polymer phase of CsC60: refocused INADEQUATE experiments.
G. Grasso, T.M. de Swiet, J.J. Titman
Journal of Physical Chemistry B (2002) 106, 8676–8680.
(3) Chemical shift anisotropy amplification.
L. Shao, C. Crockford, H. Geen, G. Grasso, J.J. Titman
Journal of Magnetic Resonance (2004) 167, 75–86.
(4) Activity of anchored human matrix metalloproteinase-1 catalytic domain on Au (111) surfaces monitored by ESI-MS.
G. Grasso, R. D’Agata, E. Rizzarelli, G. Spoto, L. D'Andrea, C. Pedone, A. Picardi, A. Romanelli, M. Fragai, K.J. Yeo
Journal of Mass Spectrometry (2005) 40, 1565–1571.
(5) In Situ AP-MALDI characterization of anchored MMPs
G. Grasso, M. Fragai, E. Rizzarelli, G. Spoto, K.J. Yeo
Journal of Mass Spectrometry (2006) 41, 1561–1569.
(6) The use of atmospheric pressure laser desorption mass spectrometry for the study of iron-gall ink
R. D’Agata, G. Grasso, S. Parlato, S. Simone, G. Spoto
Applied Physics A: Materials Science & processing (2007) 89, 91–95.
(7) A new methodology for monitoring the activity of cdMMP-12 anchored and freeze-dried on Au (111)
G. Grasso, M. Fragai, E. Rizzarelli, G. Spoto, K.J. Yeo
Journal of the American Society for Mass Spectrometry (2007) 18, 961–969.
(8) AP-MALDI/MS complete characterization of insulin fragments produced by the interaction of IDE with bovine insulin
G. Grasso, E. Rizzarelli, G. Spoto
Journal of Mass Spectrometry (2007) 42, 1590–1598.
(9) Atmospheric Pressure Laser Desorption Mass Spectrometry based methods for the study of traditional painting materials
M. Licciardello, R. D’Agata, G. Grasso, S. Simone, G. Spoto
Laser in Conservation of Artworks, Proceedings of the International Conference, LACONA VII, (2008), 67-72. Ed. M. Castillejo et al., Taylor & Francis Group, London, ISBN 978-0-415-47596-9.
(10) Real-time binding kinetics monitored with surface plasmon resonance imaging in a diffusion-free environment
R. D’Agata, G. Grasso, G. Spoto
The Open Spectroscopy Journal (2008) 2, 1–9.
(11) Ultrasensitive Detection of DNA by PNA and Nanoparticle-Enhanced Surface Plasmon Resonance Imaging
R. D’Agata, R. Corradini, G. Grasso, R. Marchelli, G. Spoto
ChemBioChem (2008) 9, 2067–2070.
(12) How the binding and degrading capabilities of insulin degrading enzyme are affected by ubiquitin
G. Grasso, E. Rizzarelli, G. Spoto
Biochimica et Biophysica Acta (2008) 1784, 1122–1126.
(13) Enzyme solid-state support assays: a surface plasmon resonance and mass spectrometry coupled study of immobilized insulin degrading enzyme
G. Grasso, A.I. Bush, R. D’Agata, E. Rizzarelli, G. Spoto
European Biophysics Journal (2009) 38, 407–414.
(14) Somatostatin: a novel substrate and a modulator of insulin degrading enzyme activity
C. Ciaccio, G.F. Tundo, G. Grasso, G. Spoto, D. Marasco, M. Ruvo, S. Marini, E. Rizzarelli, M. Coletta
Journal of Molecular Biology (2009) 385, 1556–1567.
(15) The proteolytic activity of insulin-degrading enzyme: a mass spectrometry study
G. Grasso, E. Rizzarelli, G. Spoto
Journal of Mass Spectrometry (2009) 44, 735–741.
(16) The collagen binding domain (CBD) of gelatinase A (MMP2) modulates degradation of collagen IV by gelatinase B (MMP9)
M. Gioia, S. Monaco, P.E. Van Den Steen, D. Sardella, G. Grasso, S. Marini, C.M. Overall, G. Opdenakker, M. Coletta
Journal of Molecular Biology (2009) 386, 419–434.
(17) MALDI, AP/MALDI and ESI techniques for the MS detection of amyloid-β peptides
G. Grasso, P. Mineo, E. Rizzarelli, G. Spoto
International Journal of Mass Spectrometry (2009) 282, 50–55.
(18) Chain folding and diffusion in monodisperse long n-Alkanes by Solid-state NMR
G. Grasso, J.J. Titman
Macromolecules (2009) 42(12), 4175–4180.
(19) Microfluidic Networks for Surface Plasmon Resonance Imaging Real-Time Kinetics Experiments
G. Grasso, R. D’Agata, L. Zanoli, G. Spoto
Microchemical Journal (2009) 93, 82–86.
(20) A mass spectrometry and surface enhanced Raman spectroscopy study of the interaction between carbon nanowires and noble metals
G. Grasso, L. D’Urso, E. Messina, F. Cataldo, O. Puglisi, G. Spoto, G. Compagnini
Carbon (2009) 47, 2611–2619.
(21) In situ identification of organic components of ink used in books from the 1900s by atmospheric pressure matrix assisted laser desorption ionization mass spectrometry
L. Giurato, A. Candura, G. Grasso, G. Spoto
Applied Physics A: Materials Science & processing (2009) 97, 263–269.
(22) The role of linear carbon chains on the aggregation of copper, silver and gold nanoparticles
L. D'Urso, G. Grasso, E. Messina, O. Puglisi, C. Bongiorno, V. Scuderi, S. Scalese, G. Spoto, G. Compagnini
Journal of Physical Chemistry C (2010), 114, 907–915.
(23) The use of mass spectrometry to study amyloid-β peptides
G. Grasso
Mass Spectrometry Reviews (2011), 30, 347–365.
(24) New glycoside derivatives of carnosine and analogs resistant to carnosinase hydrolysis: synthesis and characterization of their copper(II) complexes
V. Lanza, F. Bellia, R. D'Agata, G. Grasso, E. Rizzarelli, G. Vecchio
Journal of Inorganic Biochemistry (2011) 105, 181–188.
(25) Copper(I) and copper(II) inhibit Aβ peptides proteolysis by insulin-degrading enzyme differently: implications for metallostasis alteration in Alzheimer’s disease
G. Grasso, A. Pietropaolo, G. Spoto, G. Pappalardo, G.R. Tundo, C. Ciaccio, M. Coletta, E. Rizzarelli
Chemistry-A European Journal (2011) 17, 2752–2762.
(26) Spatially Resolved Mass Spectrometry: Applications in the Study of Art and Archaeological Objects
G. Spoto, G. Grasso
Trends in Analytical Chemistry (2011) 30, 856–863.
(27) Metal ions and the clearance of misfolded proteins
G. Grasso, D. La Mendola, D. Milardi
Chapter 5, RSC Drug Discovery Series No. 7
Neurodegeneration: Metallostasis and Proteostasis, Edited by Danilo Milardi and Enrico Rizzarelli, Royal Society of Chemistry 2011. (invited)
(28) Zn2+ is able to alter the distribution of Cu2+ among the available binding sites of Aβ(1-16)-polyethylenglycol-ylated peptide: implications in Alzheimer’s disease
C.A. Damante, K. Ősz, Z. Nagy, G. Grasso, G. Pappalardo, E. Rizzarelli, I. Sóvágó
Inorganic Chemistry (2011) 50, 5342–5350.
(29) Zinc(II) complexes with ubiquitin: speciation, affinity and binding features
G. Arena, R. Fattorusso, G. Grasso, G.I. Grasso, C. Isernia, G. Malgieri, D. Milardi, E. Rizzarelli
Chemistry-A European Journal (2011) 17, 11596–11603.
(30) Metallostasis and amyloid β-degrading enzymes
G. Grasso, M.L. Giuffrida, E. Rizzarelli
Metallomics (2012) 4, 937–949.
(31) Metal ions affect insulin-degrading enzyme activity
G. Grasso, F. Salomone, G.R. Tundo, G. Pappalardo, C. Ciaccio, G. Spoto, A. Pietropaolo, M. Coletta, E. Rizzarelli
Journal of Inorganic Biochemistry (2012) 117, 351–358.
(32) Formation of insulin fragments by insulin-degrading enzyme: the role of zinc(II) and cystine bridges
F. Bellia, A. Pietropaolo, G. Grasso
Journal of Mass Spectrometry (2013) 48, 135–140.
(33) Plasmonics for the study of metal ion-protein interactions
G. Grasso, G. Spoto
Analytical and Bioanalytical Chemistry (2013) 405, 1833–1843. (invited)
(34) A ratiometric naphthalimide sensor for live cell imaging of copper(I)
C. Satriano, G. Trusso Sfrazzetto, M.E. Amato, F.P. Ballistreri, A. Copani, M.L. Giuffrida, G. Grasso, A. Pappalardo, E. Rizzarelli, G.A. Tomaselli, R.M. Toscano
Chemical Communications (2013) 49, 5565–5567.
(35) Zn(II) interactions with BDNF N-terminal peptide fragments: inorganic features and biological perspectives
A. Travaglia, D. La Mendola, A. Magrì, A. Pietropaolo, V.G. Nicoletti, G. Grasso, G. Malgieri, R. Fattorusso, C. Isernia, E. Rizzarelli
Inorganic Chemistry (2013) 52, 11075–11083.
(36) The copper(II) and zinc(II) coordination mode of HExxH and HxxEH motif in small peptides: the role of carboxylate location and hydrogen bonding network
G. Grasso, A. Magrì, F. Bellia, A. Pietropaolo, D. La Mendola, E. Rizzarelli
Journal of Inorganic Biochemistry (2014) 130, 92–102.
(37) The clearance of misfolded proteins in neurodegenerative diseases by zinc metalloproteases: an inorganic perspective
G. Malgieri, G. Grasso
Coordination Chemistry Reviews (2014) 260, 139–155.
(38) The role of copper(II) and zinc(II) in the degradation of human and murine IAPP by insulin-degrading enzyme
F. Bellia, G. Grasso
Journal of Mass Spectrometry (2014) 49, 274–279.
(39) Metal complexes and metalloproteases: targeting conformational diseases
G. Grasso, S. Bonnet
Metallomics (2014) 6, 1346–1357. (invited)
(40) Monitoring the biomolecular interactions and the activity of Zn-containing enzymes involved in conformational diseases: experimental methods for therapeutic purposes
G. Grasso
Advances in Protein Chemistry and Structural Biology  Metal-Containing Enzymes (2014) 97, 115–142. (invited)
(41) The role of copper(II) in the aggregation of human amylin
A. Sinopoli, A. Magrì, D. Milardi, M. Pappalardo, P. Pucci, A. Flagiello, J.J. Titman, V.G. Nicoletti, G. Caruso, G. Pappalardo, G. Grasso
Metallomics (2014) 6, 1841–1852.
(42) Metabolism of cryptic peptides derived from neuropeptide FF precursors: the involvement of insulin-degrading enzyme
G. Grasso, P. Mielczarek, M. Niedziolka, J. Silberring
International Journal of Molecular Sciences (2014) 15, 16787–16799.
(43) A neglected modulator of insulin-degrading enzyme activity and conformation: the pH
G. Grasso, C. Satriano, D. Milardi
Biophysical Chemistry (2015) 203-204, 33–40.
(44) The insulin degrading enzyme activates ubiquitin and promotes the formation of K48 and K63 diubiquitin
G. Grasso, V. Lanza, G. Malgieri, R. Fattorusso, A. Pietropaolo, E. Rizzarelli, D. Milardi
Chemical Communications (2015) 51, 15724–15727.
(45) Copper, differently from zinc, affects bradykinin conformation, oligomerization state and activity
I. Naletova, V. G. Nicoletti, D. Milardi, A. Pietropaolo, G. Grasso
Metallomics (2016) 8, 750–761.
(46) Ubiquitin associates with the N-terminal domain of the Nerve Growth Factor: the role of Cu(II) ions
V. Lanza, A. Travaglia, G. Malgieri, R. Fattorusso, G. Grasso, G. Di Natale, V. Zito, G. Arena, D. Milardi, E. Rizzarelli
Chemistry-A European Journal (2016) 22, 17767–17775.
(47) pH sensitive functionalized graphene oxide as a carrier for delivering Gemcitabine: A computational approach
C. Sgarlata, L. D’Urso, G. Consiglio, G. Grasso, C. Satriano, G. Forte
Computational and Theoretical Chemistry (2016) 1096, 1–6.
(48) Effects of covalent modification by 4-hydroxy-2-nonenal on the noncovalent oligomerization of ubiquitin
G. Grasso, P.H. Axelsen
Journal of Mass Spectrometry (2017) 52, 36–42.
(49) Atmospheric pressure MALDI for the non-invasive characterization of carbonaceous ink from Renaissance documents
G. Grasso, M. Calcagno, A. Rapisarda, R. D’Agata, G. Spoto
Analytical and Bionalytical Chemistry (2017) 409, 3943–3950.
(50) Multiple functions of insulin-degrading enzyme: a metabolic crosslight?
G.R. Tundo, D. Sbardella, C. Ciaccio, G. Grasso, M. Gioia, A. Coletta, F. Polticelli, D. Di Pierro, D. Milardi, P. Van Endert, S. Marini, M.Coletta
Critical Reviews in Biochemistry and Molecular Biology (2017) 52, 554–582.
(51) Inhibition of Aβ amyloid growth and toxicity by silybins: the crucial role of stereochemistry
M. Sciacca, V. Romanucci, A. Zarrelli, I. Monaco, F. Lolicato, N. Spinella, C. Galati, G. Grasso, L. D'Urso, M. Romeo, L. Diomede, M. Salmona, C. Bongiorno, G. Di Fabio, C. La Rosa, D. Milardi
ACS Chemical Neuroscience (2017) 8, 1767–1778.
(52) The double faced role of copper in Aβ homeostasis: a survey on the interrelationship between metal dyshomeostasis, UPS functioning and autophagy in neurodegeneration
G. Grasso, A.M. Santoro, V. Lanza, D. Sbardella, G.R. Tundo, C. Ciaccio, S. Marini, M. Coletta, D. Milardi
Coordination Chemistry Reviews (2017) 347, 1–22.
(53) Covalent modifications of the amyloid beta peptide by hydroxynonenal: effects on metal ion binding by monomers and insights into the fibril topology
G. Grasso, H. Komatsu, P.H. Axelsen
Journal of Bioinorganic Chemistry (2017) 174, 130–136.
(54) Surface tailoring of polyacrylate-grafted graphene oxide for controlled interactions at the biointerface
G. Consiglio, P. Di Pietro, L. D'Urso, G. Forte, G. Grasso, C. Sgarlata, D. Cossement, R. Snyders, C. Satriano
Journal of Colloid & Interface Science (2017) 506, 532–542.
(55) Metals are main actors in the biological world
G. Grasso
Metals (2017) 7, 422 (Editorial)
(56) Carnosine protects pancreatic beta cells and islets against oxidative stress damage
V. Miceli, M. Pampalone, G. Frazziano, G. Grasso, E. Rizzarelli, C. Ricordi, A. Casu, G. Iannolo, P.G. Conaldi
Molecular and Cellular Endocrinology (2018) 474, 105–118.
(57) The insulin degrading enzyme is an allosteric modulator of the 20S proteasome and a potential competitor of the 19S
D. Sbardella, G.R. Tundo, A. Coletta, J. Marcoux, E.I. Koufogeorgou, C. Ciaccio, A.M. Santoro, D. Milardi, G. Grasso, P. Cozza, M.-P. Bousquet-Dubouch, S. Marini, M. Coletta
Cellular and Molecular Life Sciences (2018) 75, 3441–3456.
(58) "Enzyme Kinetics from Circular Dichroism of Insulin..." by Noel D. Lazo (invited commentary)
G. Grasso
Bioscience Reports (2018) 38, BSR20181555.
(59) Amyloid beta proteins modified by PUFA oxidation products in Alzheimer’s disease brain
H.A. Mourelatos, H. Komatsu, R. Furman, G. Grasso, P.H. Axelsen
Biophysical Journal 114(3):229a-230a DOI: 10.1016/j.bpj.2017.11.1277
(60) Mass spectrometry is a multifaceted weapon to be used in the battle against Alzheimer’s disease: amyloid beta peptides and beyond
G. Grasso
Mass Spectrometry Reviews (2019) 38, 34–48.
(61) Site directed mutagenesis of insulin-degrading enzyme allows singling out the molecular basis of peptidase versus E1-like activity: the role of metal ions
F. Bellia, V. Lanza, I. Mohamed Mohamud Ahmed, S. Garcia-Vinuales, E. Veiss, M. Arizzi, D. Calcagno, D. Milardi, G. Grasso
Metallomics (2019) 11, 278–281.
(62) Ubiquitin binds the Amyloid β peptide and interferes with its clearance pathways
F. Bellia, V. Lanza, S. García-Viñuales, I. M. M. Ahmed, A. Pietropaolo, C. Iacobucci, G. Malgieri, G. D’Abrosca, R. Fattorusso, V. G. Nicoletti, D. Sbardella, G. R. Tundo, M. Coletta, D. Calcagno, L. Pirone, E. Pedone, G. Grasso, D. Milardi
Chemical Science (2019) 10, 2732–2742.
(63) IDE degrades Nociceptin/Orphanin FQ through an insulin regulated mechanism
G.A. Zingale, F. Bellia, I.M.M. Ahmed, P. Mielczarek, J. Silberring, G. Grasso
International Journal of Molecular Science (2019) 20, 4447–4457.
(64) Pyrazolones activate proteasome by gating mechanisms and protect neuronal cells from Aβ amyloid toxicity
A.M. Santoro, V. Lanza, F. Bellia, D. Sbardella, G.R. Tundo, A. Cannizzo, G. Grasso, M. Arizzi, V.G. Nicoletti, S. Alcaro, G. Costa, A. Pietropaolo, G. Malgieri, G. D'Abrosca, R.o Fattorusso, S. García-Viñuales, I.M.M. Ahmed, M. Coletta, D. Milardi
ChemMedChem (2020) 15, 302–316.
(65) The use of mass spectrometry to study Zn-metalloprotease-substrate interactions
G. Grasso
Mass Spectrometry Reviews (2020) 39, 574–585.
(66) Defective proteasome biogenesis into skin fibroblasts isolated from Rett Syndrome subjects with MeCP2 non-sense mutations
D. Sbardella; G.R. Tundo; V. Cunsolo; G. Grasso; R. Cascella; V. Caputo; A.M. Santoro; D. Milardi; A. Pecorelli; C. Ciaccio; D. Di Pierro; S. Leoncini; L. Campagnolo; V. Pironi; F. Oddone; P. Manni; S. Foti; E. Giardina; C. De Felice; Y. Hayek; P. Curatolo; C. Galasso; G. Valacchi; M. Coletta; G. Graziani; S. Marini
BBA - Molecular Basis of Disease (2020) 1866, 165793.
(67) The proteasome as a druggable target with multiple therapeutic potentialities: cutting and non‐cutting edges
G.R. Tundo, D. Sbardella, A.M. Santoro, A. Coletta, F. Oddone, G. Grasso, D. Milardi, P. Lacal, S. Marini, P. Purrello, G. Graziani, M. Coletta
Pharmacology & Therapeutics (2020) 107579.
(68) The insulin-degrading enzyme as a link between insulin and neuropeptides metabolism
D. Wacławczyk, J. Silberring, G. Grasso
Journal of Enzyme Inhibition and Medicinal Chemistry (2021) 36, 183–187.
(69) The interplay between lipid and Aβ amyloid homeostasis in Alzheimer’s Disease: risk factors and therapeutic opportunities
S. García-Viñuales, M.F.M. Sciacca, V. Lanza, A.M. Santoro, G. Grasso, G.R. Tundo, D. Sbardella, M. Coletta, G. Grasso, C. La Rosa, D. Milardi
Chemistry and Physics of Lipids (2021) 236, 105072.
(70) Critical appraisal of the European Union Scientific Committee on Health, Environmental and Emerging Risks (SCHEER) Preliminary Opinion on electronic cigarettes
Renée O’Leary et al. Harm Reduct J (2021) 18:31.
(71) Analysis of common methodological flaws in the highest cited e cigarette epidemiology research
C. Hajat, E. Stein, A. Selya, R. Polosa, The CoEHAR study group
Internal and Emergency Medicine (2022) 17, 887–909.
(72) Insulin-Degrading Enzyme is a non proteasomal target of carfilzomib and affects the 20S proteasome inhibition by the drug
G.R. Tundo, D. Sbardella, F. Oddone, G. Grasso, S. Marini, M.G. Atzori, A.M. Santoro, D. Milardi, F. Bellia, G. Macari, G. Graziani, F. Polticelli, P. Cascio, M. Parravano, M. Coletta
Biomolecules (2022) 12, 315.
(73) The neuroprotective effect of carnosine is mediated by insulin-degrading enzyme
A. Distefano, G. Caruso, V. Oliveri, F. Bellia, D. Sbardella, G.A. Zingale, F. Caraci, G. Grasso
ACS Chemical Neuroscience (2022) 13, 1588−1593.
(74) An SPR based method for Hill coefficient measurements: the case of insulin-degrading enzyme
A. Distefano, G.A. Zingale, G. Grasso
Analytical and Bionalytical Chemistry (2022) 414, 4793−4802.
(75) Carbon dots surface chemistry drives fluorescent properties: new tools to distinguish isobaric peptides
A. Distefano, F Calì, M. Gaeta, N. Tuccitto, A. Auditore, A. Licciardello, A. D’Urso, K.-J. Lee, O. Monasson, E. Peroni, G. Grasso
Journal of Colloid and Interface Science (2022) 625, 405−414.
(76) Dipyridamole fluorescent properties depend on the specific aggregation pathways of the amyloidogenic protein: different responses from insulin, amylin and amyloid- peptides
F. Laneri, S. García-Viñuales, V. Lanza, N. Licciardello, D. Milardi, S. Sortino, G. Grasso
Archives of Biochemistry and Biophysics (2022) 728, 10935.
(77) A novel SPR based method for measuring diffusion coefficients: from small molecules to supramolecular aggregates
G.A. Zingale, I. Pandino, A. Distefano, N. Tuccitto, G. Grasso
Biosensors & Bioelectronics: X (2023) 13, 100306.
(78) GxxxG motif stabilize ion-channel like pores through Cα―H‧‧‧O interaction in Aβ (1-40)
C. Rando, G. Grasso, D. Sarkar, M.F.M. Sciacca, L.M. Cucci, A. Cosentino, G. Forte, M. Pannuzzo, C. Satriano, A. Bhunia, C. La Rosa
International Journal of Molecular Sciences (2023) 24, 2192.
(79) The use of Surface Plasmon Resonance to study the interactions of proteins involved in conformational diseases: experimental approaches for new therapeutical perspectives
G.A. Zingale, A. Distefano, G. Grasso
Current Medicinal Chemistry (2023) 30, 4072-4095.
(80) Carbon dots as a versatile tool to monitor insulin aggregation
G.A. Zingale, A. Distefano, I. Pandino, N. Tuccitto, V. Oliveri, M. Gaeta, A. D’Urso, A. Arcoria, G. Grasso
Analytical and Bioanalytical Chemistry (2023) 415:1829–1840.
(81) Insights into the binding of Ag ions with SilE model peptides: an NMR and MS coupled approach
G.A. Zingale, V. Oliveri, G. Grasso
Metallomics (2023) 15, mfad015
(82) Time-of-Flight SIMS Investigation of Peptides Containing Cell Penetrating Sequences
A. Auditore, N. Tuccitto, G. Grasso, O. Monasson, E. Peroni, A. Licciardello
Biointerphases (2023) 1, 18, 031006.
(83) The Insulin-degrading Enzyme from Structure to Allosteric Modulation: New Perspectives for Drug Design
G.R. Tundo, G. Grasso, M. Persico, O. Tkachuk, F. Bellia, A. Bocedi, S. Marini, M. Parravano, G. Graziani, C. Fattorusso, D. Sbardella
Biomolecules (2023) submitted
(84) A newly developed Surface Plasmon Resonance method for measuring molecular diffusion coefficients
I. Pandino, G.A. Zingale, N. Tuccitto, G. Grasso
Methods (2023) submitted

PARTICIPATION TO SCIENTIFIC MEETINGS:
(1) G.A. Zingale, I. Pandino, D. Sbardella, G. Grasso, The use of mass spectrometry in conformational diseases, 5th Central European Biomedical Congress, Future trends in health interventions Kraków, Poland May 29 - June 1, 2023, Invited Oral Communication.
(2) A. Distefano, N. Tuccitto, A. Auditore, A. Licciardello, V. Cunsolo, O. Monasson, E. Peroni and G. Grasso, Mass spectrometric investigation of isobaric peptides of biological interest: ESI-MS versus ToF-SIMS, 39th Informal Meeting on Mass Spectrometry, Paris, France, May 15-17, 2023, Oral Communication.
(3) A. Distefano, G.A. Zingale, N. Tuccitto, G. Grasso, Carbon dots as a versatile tool to monitor insulin aggregation. Workshop: “I chimici per le biotecnologie”, Naples (Italy), 27/02/2023, Poster.
(4) G. Grasso, G.A. Zingale, I. Pandino, A. Distefano. “Determination of biomolecules conformational, oligomerization and metal-binding features by measuring diffusion coefficients with a common SPR instrument” International Symposium on Pathomechanisms of Amyloid Diseases, Catania (Italy) 25th-27th August 2022, Oral Communication.
(5) G. Grasso, G.A. Zingale, I. Pandino, A.G. Arcoria, A. Distefano, N. Tuccitto. “New Experimental Techniques to study Intrinsically Disordered Proteins” 26th June-1st July, 2022 • Les Diablerets Conference Center • Gordon Research Conference, Intrinsically Disordered Proteins, Ginevra (Switzerland), Poster.
(6) A. Distefano, V. Oliveri, G. Grasso. “The search for IDE activity modulators: new perspectives for therapeutic potentials in Alzheimer’s disease”. The Merck Young Chemists' Symposium 2021, 22nd-24th November, Rimini (Italy), Poster.
(7) G. Grasso, F. Bellia, V. Lanza, I.M.M. Ahmed, S. Garcia-Vinuales, M. Arizzi, D. Calcagno, D. Milardi, “Site directed mutagenesis of insulin-degrading enzyme allows singling out the molecular basis of peptidase versus E1-like activity: the role of metal ions”, Metallomics, 30th June -3rd July 2019, Varsavia (Polonia), Oral Communication.
(8) G. Grasso, M. Arizzi, A. Cannizzo, V. Nicoletti, D. Milardi, A.M. Santoro, V. Lanza, F. Bellia, M. Coletta, D. Sbardella, S. Marini, G.R. Tundo, “Ubiquitin-proteasome system derangement in brain pathologies: new neuroprotective strategies”, ADPD2019, 14th International Conference on Alzheimer's and Parkinson's Diseases, Lisbon, 26th-31st March 2019 (Portugal), Poster.
(9) G. Grasso, F. Bellia, V. Lanza, S. García-Viñuales, A. Pietropaolo, C. Iacobucci, G. Malgieri, R. Fattorusso, V.G. Nicoletti, D. Sbardella, G.R. Tundo, M. Coletta, D. Milardi, “Aβ40 competitively binds Ubiquitin and inhibits polyubiquitination: a new paradigm for amyloid toxicity”, Convegno Nazionale della Divisione di Chimica dei Sistemi Biologici, Caserta, 26-28 September 2018 (Italy), Oral Communication.
(10) G. Grasso, M. Arizzi, D. Calcagno, A. Cannizzo, V.G. Nicoletti, A.M. Santoro, V. Lanza, F. Bellia, D. Sbardella, G.R. Tundo, S. Marini, M. Coletta, D. Milardi, “Ubiquitin-proteasome system derangement in brain pathologies: new neuroprotective strategies”, Proteolytic Enzymes and Their Inhibitors, Gordon Research Conference, Understanding Proteases and Their Roles as Regulators of Health and Disease, June 3-8, 2018, Renaissance Tuscany Il Ciocco, Lucca (Barga), Italy, Poster.
(11) H.A. Mourelatos, H. Komatsu, R. Furman, G. Grasso, P.H. Axelsen, “Amyloid beta proteins modified by PUFA oxidation products in Alzheimer's disease brain”, 62nd Annual Meeting of the Biophysical Society, 17-21 February 2018, San Francisco, California, USA, Poster
(12) G. Grasso, H. Komatsu, P.H. Axelsen, “The role of Amyloid beta protein, metal ions and oxidative stress in the pathophysiology of Alzheimer’s disease: recent findings”, 14th International Symposium on Applied Bioinorganic Chemistry, 7th-10th June 2017, Toulouse, France, Poster.
(13) G. Grasso, P.H. Axelsen, H. Komatsu, “The use of mass spectrometry to study the covalent modification of amyloid beta protein due to oxidative stress: insights into the pathophysiology of AD”, 35th Informal Meeting on Mass Spectrometry, 07th-11th May 2017, Aussois, France, Oral Communication.
(14) D. Sbardella, G.R. Tundo, J. Marcoux, A. Coletta, D. Di Pierro, G. Grasso, A.M. Santoro, C. Ciaccio, S. Marini, M.-P. Bousquet-Dubouch, P. Van Endert, M. Coletta, “Insulin degrading enzyme activates the 20S proteasome and competes with canonical regulatory particles”, ZOMES IX Conference, 14th-17th February 2017, Rome, Italy, Poster.
(15) H. Komatsu, C. Meurice, G. Grasso, L.G. Lippert, Y.E. Goldman, P.H. Axelsen, “Variable binding of thioflavin T by amyloid fibrils”, 61st Annual Meeting of the Biophysical Society, 11th -15th February 2017, New Orleans, Louisiana, USA, Poster.
(16) G. Grasso, H. Komatsu, P.H Axelsen, “The role of Amyloid beta protein, metal ions and oxidative stress in the pathophysiology of Alzheimer’s disease: recent findings”, XVI Workshop on Pharmacobiometallics, 28th‐29th October 2016, Messina, Italy, Oral Communication.
(17) G. Grasso, “Monitoring the biomolecular interactions and the activity of Zn-containing enzymes involved in conformational diseases: experimental methods for therapeutic purposesXII International Conference Biomolecules: Identification and Functions” XII International Conference Biomolecules: Identification and Functions, 21st-22nd October 2016, Krakow, Poland, Invited Lecture.
(18) D. Sbardella, G.R. Tundo, V. Cunsolo, G. Grasso, M. Santarone, V. Muccilli, R. Saletti, C. Ciaccio, D. Di Pierro, C. De Felice, Y. Hayek, G. Valacchi, L. Campagnolo, A. Orlandi, C. Galasso, P. Curatolo, M. Coletta, S. Marini. “Dys-regulation of the Intracellular Proteolytic Systems in Rett Syndrome” 7th Proteasome and Autophagy Workshop, 6th-8th April 2016, Clermont-Ferrand, France, Poster.
(19) V. Miceli, G. Frazziano, G. Grasso, E. Rizzarelli, G. Iannolo, P.G. Conaldi, “Protective effect of carnosine on oxidative stress injury in pancreatic β–cells”. OXYGEN CLUB OF CALIFORNIA WORLD CONGRESS 2015, 24th-26th June 2015, Valencia, Spain, Poster.
(20) G. Grasso, F. Bellia, D. Milardi, A. Pietropaolo, “Metal ions modulate the cryptic peptides generated by insulin-degrading enzyme in a substrate-dependent manner”, 13th International Symposium on Applied Bioinorganic Chemistry (ISABC13) 12th -15th June 2015, Galway, Ireland, Invited lecture.
(21) F. Bellia, G; Grasso, D. Milardi, E. Rizzarelli, “Endogenous inhibitors of amyloid-beta degradation: structural and functional aspects” 6th European Conference Chemistry in the Life Sciences. 10th -12th June 2015, Lisbon (Portugal), Oral communication.
(22) G. Grasso, “The application of Mass Spectrometry for the analysis of the cryptic peptides produced by the action of IDE on some of its substrates”, 33rd Informal Meeting on Mass Spectrometry, 10th -14th of May 2015, Szczyrk, Poland, Oral Communication.
(23) G. Spoto, A. Rapisarda, G. Grasso, R. D'Agata, A. Aura, M. C. Giuffrida, M. Calcagno, C. Valenti, “Atmospheric pressure MALDI-MS for the direct analysis of carbonaceous inks used in XVII century manuscripts”, Technart 2015, 27th -30th April 2015, Catania, Italy, Poster.
(24) G. Grasso, D. Milardi, V. Lanza, F. Bellia, J. Silberring, P. Mielczarek, E. Rizzarelli, “Insulin-degrading enzyme: a metalloprotease whose activity can be modulated for therapeutic purposes”, XXV Congresso Nazionale della Società Chimica Italiana, 7th -12th of September 2014, Rende (CS), Italy, Keynote. (invited)
(25) G. Grasso, D. Milardi, V. Lanza, F. Bellia, E. Rizzarelli, “Insulin-Degrading Enzyme and Ubiquitin: a New Perspective”, Gordon Research Conference, Proteolytic Enzymes & Their Inhibitors. Dysfunction in Disease, Mechanism and Therapeutic Targeting- 22th -27th June 2014, Lucca (Barga), Italy, Poster.
(26) G. Grasso, F. Bellia, D. La Mendola, A. Magrì, A. Pietropaolo, E. Rizzarelli, “Metalloproteases and metal ions in Alzheimer’s disease: recent findings”, Gordon Research Seminar, Proteolytic Enzymes & Their Inhibitors. Proteases: Making the Cut in Biological Processes and Diseases- 21th-22th June 2014, Lucca (Barga), Italy, Poster.
(27) G. Grasso, F. Bellia, D. La Mendola, A. Magrì, A. Pietropaolo, E. Rizzarelli, “Metalloproteases and metal ions in Alzheimer’s disease: recent findings” XIII Workshop on PharmacoBioMetallics – 25th -26th October 2013, Catania, Italy, p. 32, Oral Communication.
(28) F. Bellia, G. Grasso, E. Rizzarelli, “Nuova attività di metallodipeptidasi e potenziali effetti nella neuro degenerazione” Convegno congiunto di Calabria e Sicilia della Società Chimica Italiana – 2nd-3rd December 2013, Catania, Oral Communication.
(29) F. Bellia, G. Grasso, E. Rizzarelli, “News on the role of carnosinase in neurodegeneration” XVI International Conference on Biological Inorganic Chemistry (ICBIC 16). July 22nd-26th, 2013, Grenoble (France), Oral Communication.
(30) G. Grasso, F. Bellia, D. La Mendola, A. Magrì, A. Pietropaolo, E. Rizzarelli, “Metalloproteases and metal ions in Alzheimer’s disease: recent findings” XLI Congresso Nazionale di Chimica Inorganica, Parma, Italy, 3rd-6th September 2013, OC3, Oral Communication.
(31) G. Grasso, E. Rizzarelli, F. Bellia, A. Magrì, D. La Mendola, “Metalloproteases and metal ions in Alzheimer’s disease: recent findings”. Metallomics, Oviedo, Spain 8th-11th July 2013, OP 45, Oral Communication.
(32) F. Bellia, G. Grasso, E. Rizzarelli, “The role of metalloproteases in neurodegeneration: Recent findings” Neuroscience 2012 – 13th-17th October 2012, New Orleans (US-LA), Poster.
(33) G. Grasso, D. La Mendola, A. Magrì, E. Rizzarelli, “Metal ions binding to the catalytic site of metalloproteases: recent findings”. BIOMET 12, Padova, Italy, 26th-28th October 2012, p. 55, Poster.
(34) G. Grasso, F. Bellia, A. Pietropaolo, E. Rizzarelli, “The role of metalloproteases in Alzheimer’s Disease: recent findings”. Convegno Nazionale della Divisione di Chimica nei Sistemi Biologici, Napoli, Italy, 24th-25th September 2012, p. 51, Oral Communication.
(35) G. Grasso, F. Bellia, A. Pietropaolo, G. Spoto, E. Rizzarelli, “The role of metalloproteases in Alzheimer’s Disease: recent findings”. 30th Informal Meeting on Mass Spectrometry, Olomouc, Czech Republic, 29th April – 3rd May 2012, p. 39, Oral Communication.
(36) F. Bellia, G. Grasso, F. Guarino, V. De Pinto, E. Rizzarelli, “The important role of human serum carnosinase in neurodegeneration” 12th Eurasia Conference on Chemical Sciences – 16th-21th April 2012, Corfù (Greece), Oral Communication.
(37) G. Grasso, F. Bellia, C. Tosto, D. Milardi, E. Rizzarelli, “The influence of metallostasis on Insulin Degrading Enzyme activity”. 11th International Symposium on applied bioinorganic chemistry, Barcelona, Spain, 2nd-5th December 2011, p. OC30, Oral Communication.
(38) G. Grasso, A. Pietropaolo, G. Spoto, G. Pappalardo, E. Rizzarelli, “The influence of metallostasis on the interaction between insulin-degrading enzyme and different peptides”. Third International Symposium on Metallomics. Münster, Germany, 15th-18th June 2011, p.9, Oral Communication.
(39) G. Grasso, A. Pietropaolo, G. Spoto, G. Pappalardo, G. R. Tundo, C. Ciaccio, M. Coletta and E. Rizzarelli. “Copper(I) and copper(II) inhibit Aβ peptides proteolysis by insulin-degrading enzyme differently: implications for metallostasis alteration in Alzheimer’s disease”. Tenth Workshop on Pharmaco-Bio-Metallics. Pozzuoli, Italy, 29th-30th October 2010, p.27, Oral Communication.
(40) D. Milardi, G. Grasso, G.I. Grasso, G. Malgieri, C. Isernia, R. Fattorusso, G. Arena and E. Rizzarelli. “The inorganic side of Ubiquitin”. Ubiquitin Drug Discovery and Diagnostics. Philadelphia, USA, 13th-14th October 2009, p.62, Poster.
(41) F. Bellia, V. Lanza, R. D'Agata, G. Grasso, E. Rizzarelli, G. Vecchio, “New carnosine derivatives and analogs: synthesis, carnosinase resistance and characterization of their copper(II) complexes” Convegno della Società Chimica Italiana – Divisione di Chimica dei Sistemi Biologici. 9th–11th September 2010, S. Vito di Cadore (BL), Oral Communication.
(42) G. Grasso, R. D’Agata, L. Zanoli, A. Candura, G. Spoto. “In situ identification of organic components of ink used in the 1900s century books by atmospheric pressure matrix assisted laser desorption ionization mass spectrometry”. Precise processing of materials for art diagnostics, characterization, identification & restoration. Strasburgo, France, 8th-12th June 2009, p.16, Oral Communication.
(43) G. Grasso, F. Salomone, C.A. Damante. “The influence of metal ions on the interaction between insulin-degrading enzyme and Aβ peptides”. 27th Informal Meeting on Mass Spectrometry. Retz, Austria, 3rd-6th May 2009, p.93, Oral Communication.
(44) G. Grasso, C. Ciaccio, M. Coletta, R. D’Agata, E. Rizzarelli, G. Spoto. “The role of insulin-degrading enzyme in AD”. Meeting FIRB 2009. Verona, Italy, 23rd-24th April 2009, p.12, Oral Communication
(45) G. Grasso, F. Salomone, C.A. Damante, G. Spoto, G. Pappalardo, E. Rizzarelli. “Influence of metal ions on the interaction between insulin-degrading enzyme and Aβ peptides”. Symposium and meeting on "Systemic Amyloidoses and related issues". Amsterdam, Holland, 3rd-4th April 2009, p.24, Oral Communication.
(46) L. D'Urso, G. Grasso, E. Messina, G. Spoto, G. Compagnini. “The interaction between carbon nanowires and metals: a mass spectrometry and SERS study”. XXI Congresso Nazionale GNSR 2009. Milan, Italy, 10th-13th febbraio 2009, p.72, Oral Communication.
(47) G. Grasso, E. Rizzarelli, G. Spoto. “The proteolytic activity of insulin degrading enzyme: a SPR-MS coupled study”. Symposium and meeting on “Systemic Amyloidoses and related issues”. Porto, Portugal, 17th-18th October 2008, p.28, Oral Communication.
(48) G. Grasso, E. Rizzarelli, G. Spoto. “The proteolytic activity of insulin degrading enzyme: a SPR-MS coupled study”. 26th Informal Meeting on Mass Spectrometry, Fiera di Primiero, Italy 4th-8th May 2008, p.40, Oral Communication.
(49) G.R. Tundo, C. Ciaccio, G. Grasso, G. Spoto, D. Marasco, M. Ruvo, S. Marini, E. Rizzarelli, M. Coletta. “Somatostatin: a novel substrate and a modulator of insulin degrading enzyme activity”. Meeting FIRB 2008, Lecce, Italy, 13th-14th March 2008, p.25, Oral Communication.
(50) G. Grasso, E. Rizzarelli, G. Spoto. “The proteolytic activity of insulin degrading enzyme: a SPR-MS coupled study”. Meeting FIRB 2008, Lecce, Italy, 13th-14th March 2008, p.32, Oral Communication
(51) G. Grasso, E. Rizzarelli, G. Spoto. “Binding capability of insulin degrading enzyme is affected by ubiquitin”. Symposium and meeting on “Systemic Amyloidoses and related issues”. Charité, Berlin, Germany, 15th-16th February 2008, p.23, Oral Communication
(52) G. Grasso, R. D’Agata, E. Rizzarelli, G. Spoto. “L’interazione dell’insulin-degrading enzyme con alcuni dei suoi substrati naturali: uno studio SPR/MS”. Convegno Congiunto delle Sezioni Calabria e Sicilia, Messina, Italy, 3rd-4th December 2007, p.C02, Oral Communication
(53) G. Grasso, R. D’Agata, E. Rizzarelli, G. Spoto. “L’interazione dell’insulin-degrading enzyme con alcuni dei suoi substrati naturali: uno studio SPR/MS”. 7th Workshop on PharmacoBioMetallics, Palermo, Italy 26th-28th October 2007, p.20, Oral Communication
(54) R. D'Agata, G. Grasso, G. Spoto, P. Cremonesi, S. Simone. “Atmospheric pressure laser desorption mass spectrometry based methods for the study of traditional ink and painting materials”. LACONA VII: International Conference on Laser in the Conservation of Art Works. Madrid, Spain, 17th-21th September, 2007, p.58, Oral Communication
(55) G. Grasso, R. D’Agata, E. Rizzarelli, G. Spoto. “AP/MALDI-MS Study of the interaction between Insulin Degrading Enzyme and Insulin” 2nd ItPA Conference, Acitrezza (Catania), Italy, 26th-29th June 2007, p.160, Poster
(56) R. D’Agata, G. Grasso, G. Spoto. “Coupling microfluidic networks and surface plasmon resonance imaging for proteomic biosensing”. 2nd ItPA Conference, Acitrezza (Catania), Italy, 26th-29th June 2007, p.23, Oral Communication
(57) R. D'Agata, G. Grasso, S. Simone, P. Cremonesi, G. Spoto. “The use of atmospheric pressare laser desorption mass spectrometry for the study of traditional painting materials”. Workshop on Science & Technology of Cultural heritage Materials: Art conservation and Restoration. Strasburgo, France, 28th May – 1st Giugno, 2007, p.S9-8, Oral Communication
(58) G. Grasso, E. Rizzarelli, G. Spoto. “The interaction of insulin-degrading enzyme with bovine insulin: an AP/MALDI-MS study”. 25th Informal Meeting on Mass Spectrometry, Nyiregyháza-Sóstó, Hungary, 6th-10th May 2007, p.30, Oral Communication
(59) G. Grasso, M. Fragai, E. Rizzarelli, G. Spoto, K.J. Yeo. “In situ MALDI-MS characterization of MMPs anchored on gold surfaces”. 9th International Symposium on Applied Bioinorganic Chemistry, Naples, Italy, 2nd-5th December 2006, p.18, Oral Communication
(60) G. Grasso, M. Fragai, E. Rizzarelli, G. Spoto, K.J. Yeo. “In situ MALDI-MS characterization of MMPs anchored on gold surfaces”. 6th Pharmacobiometallics, Real Museo di Mineralogia, Naples, Italy, 30th November-1st December 2006, p.33, Oral Communication
(61) S. Parlato, R. D’Agata, G. Grasso, S. Simone, G. Spoto. “AP-MALDI-MS nello studio di materiali di interesse artistico”. XXII Congresso Nazionale della Società Chimica Italiana, Florence, Italy, 10th-15th September 2006, p.113, ANA-P-75, Poster
(62) S. Parlato, R. D’Agata, P. Cremonesi, G. Grasso, G. Spoto. “Uso di tecniche di spettrometria di massa a desorbimento laser nell’identificazione di leganti pittorici”. XXII Congresso Nazionale della Società Chimica Italiana, Florence, Italy, 10th-15th September 2006, p.84,ANA-O-28, Oral Communication
(63) R. D'Agata, G. Grasso, G. Spoto. “Microfluidic based approaches for surface plasmon resonance imaging experiments”. 11th International Meeting on Chemical Sensors, Brescia, Italy, 16th-19th July 2006, p.15, Oral Communication
(64) G. Grasso, G. Spoto, E. Rizzarelli, M. Fragai, K.J. Yeo “In situ MALDI-MS characterization of MMPs anchored on gold surfaces”. 24th Informal Meeting on Mass Spectrometry, Ustròn, Poland, 14th-18th May 2006, p.21, Oral Communication
(65) R. D'Agata, G. Grasso, G. Spoto. “New strategies for the use of surface plasmon resonance imaging in the study of biomolecular interactions”. Incontro di Spettroscopia Analitica (ISA), Giovinazzo (BA), Italy, 9th-12th April 2006, p.8, Oral Communication
(66) G. Grasso, R. D’Agata, E. Rizzarelli, G. Spoto, L. D'Andrea, C. Pedone, A. Picardi, A. Romanelli, M. Fragai, C. Luchinat, K.J. Yeo. “Coupling FT-SPR and ESI-MS techniques to monitor in a quantitative fashion the activity of two different MMP’s anchored on a gold surface”. V Symposium Pharmaco-Bio-Metallics, Centro Residenziale Universitario di Bertinoro, Italy 10th-13th November 2005, p.71, Oral Communication
(67) G. Grasso, R. D’Agata, E. Rizzarelli, G. Spoto, L. D'Andrea, C. Pedone, A. Picardi, A. Romanelli, M. Fragai, C. Luchinat, K.J. Yeo. “Coupling FT-SPR and ESI-MS techniques to monitor in a quantitative fashion the activity of two different MMP’s anchored on a gold surface”. 8th FIGIPAS meeting in inorganic chemistry, Athens, Greece, 6th-9th July 2005, p.OP31, Oral Communication
(68) G. Grasso, R. D’Agata, E. Rizzarelli, G. Spoto, L. D'Andrea, C. Pedone, A. Picardi, A. Romanelli, M. Fragai, K.J. Yeo. “Activity of anchored MMP1 on Au (111) surfaces monitored by ESI-MS”. 23rd Informal Meeting on Mass Spectrometry, Fiera di Primiero, Italy, 15th-19th May 2005, p.102, Poster
(69) G. Grasso, J. Titman. “Chain folding, diffusion and dynamics in long normal alkanes”. The 3rd Alpine Conference on Solid-State NMR, Chamonix Mont-Blanc, France, 14th-18th September 2003, p.P58, Poster
(70) G. Grasso, T. De Swiet, J. Titman. “Solid-State NMR study of an alkali fulleride”. 43rd Experimental Nuclear Magnetic Resonance Conference, Asilomar Conference Center, California, USA, 14th-19th April 2002, p.127, M/T P086, Poster
(71) G. Grasso, T. De Swiet, J. Titman. “Solid-State NMR study of an alkali fulleride”. The 2nd Alpine Conference on Solid-State NMR, Chamonix Mont-Blanc, France, 9th-13th September 2001, p.T23, Oral Communication

COURSES
• 2016 Fulbright Visiting Scholar Enrichment Seminar, Seattle (USA): Where International Efforts to Combat Climate Change Converge, April 14-17, 2016
• NMR school, Torino, Italy, 2007.
• Second EuCheMS School on Protein Chemistry, protein-protein interaction: from genome to functions. Alba di Canazei, Verona, Italy, 2006.
• X School in Bioinorganic Chemistry, Catania, Italy, 2005.

ORGANIZATION OF SCIENTIFIC EVENTS
Workshop Chimica analitica di processo, Villa Citelli, Catania, 27th April 2007

OTHER INTERESTS
Author of the Novel: Immortalizer. La vita dalla morte, edited by Leonida, 2022. ISBN: 8833741664
Travelling: Around Europe, India, Nepal and USA
Reading and writing: Science books, novels.