LAZZARINO Giuseppe

Professore Ordinario

Orari di ricevimento

Mercoledì e giovedì dalle 10 alle 12

Curriculum

PROF. G. LAZZARINO - SHORT CV

Biography

Prof. Giuseppe Lazzarino has received his Degree in Biological Sciences at the State University of Rome "La Sapienza", Rome, Italy in 1979. In 1980 he joined an Italian pharmaceutical company, becoming head of the Biochemistry and Pharmacology Research Laboratory. In 1986 he became Researcher in Biochemistry at the University of Rome "Tor Vergata", Rome, Italy. Since 1994 he is Full Professor of Biochemistry at the School of Biology of the University of Catania, Catania, Italy (Department of Biomedical and Biotechnological Sciences, Division of Medical Biochemistry). During his career he collaborated with different national and international research groups carrying out research projects of common interest. Since the end of 2010 he established a spin-off company mainly aimed to evidence biochemical markers of clinical interests and to develop proper diagnostic kits, particularly dedicated to male infertility and neurodegenerations (multiple sclerosis), as well as to perform metabolic screenings of biological fluids for prenatal and postnatal diagnosis of IEM. He authored more than 130 papers (Scopus) in the field of biochemistry and, mostly, of translational medicine (neurotraumatology, cardiology, neurodegeneration, male infertility). He holds 8 patents.

Research interests

Biochemistry, clinical biochemistry and translational medicine are the main areas of interest in our laboratory. In particular, we are interested in studying: 1) energy metabolism and free radical damage in animals and human beings; 2) biochemical and molecular mechanisms of cell damages in traumatic brain injury; 3) biochemical aspects of male infertility; 4) biochemical markers of clinical relevance in acute and chronic neurodegenerations, and in male and female infertilities; 5) set up of analytical methods for low molecular weight compounds in biological samples; 6) biochemical and molecular evaluation of IEM (inborn errors of metabolism).




Giuseppe Lazzarino record scores

METRICS (Data obtained from Scopus on the 20th of July 2020)

Total number of papers : 139

h-index: 39

Total number of citations: 4889

Mean number of citations: 35.17



FULL LENGTH IMPACTED PAPERS


1. Giallongo C, Tibullo D, Puglisi F, Barbato A, Vicario N, Cambria D, Laura Parrinello NL, Romano A, Conticello C, Forte S, Parenti R, Amorini AM, Lazzarino G, Li Volti G , Palumbo GA, Di Raimondo F. Inhibition of TLR4 Signaling Affects Mitochondrial Fitness and Overcomes Bortezomib Resistance in Myeloma Plasma CellsCancers 2020, 12, 1999; doi:10.3390/cancers12081999.

2. Caruso G, Musso N, Grasso M, Costantino A, Lazzarino G, Tascedda F, Gulisano M, Lunte SM, Caraci F. Microfluidics as a Novel Tool for Biological and Toxicological Assays in Drug Discovery Processes: Focus on Microchip Electrophoresis. Micromachines (Basel). 2020 Jun 15;11(6):593. doi: 10.3390/mi11060593.

3. Tibullo D, Giallongo C, Romano A, Vicario N, Barbato A, Puglisi F, Parenti R, Amorini AM, Wissam Saab M, Tavazzi B, Mangione R, Brundo MV, Lazzarino G, Palumbo GA, Volti GL, Raimondo FD, Lazzarino G. Mitochondrial Functions, Energy Metabolism and Protein Glycosylation are Interconnected Processes Mediating Resistance to Bortezomib in Multiple Myeloma Cells. Biomolecules. 2020 Apr 30;10(5):696. doi: 10.3390/biom10050696.

4. Di Pietro V, Yakoub KM, Caruso G, Lazzarino G, Signoretti S, Barbey AK, Tavazzi B, Lazzarino G, Belli A, Amorini AM. Antioxidant Therapies in Traumatic Brain Injury. Antioxidants (Basel). 2020 Mar 22;9(3):260. doi: 10.3390/antiox9030260.

5. Fresta CG, Fidilio A, Lazzarino G, Musso N, Grasso M, Merlo S, Amorini AM, Bucolo C, Tavazzi B, Lazzarino G, Lunte SM, Caraci F, Caruso G. Modulation of Pro-Oxidant and Pro-Inflammatory Activities of M1 Macrophages by the Natural Dipeptide Carnosine. Int J Mol Sci. 2020;21(3). doi: 10.3390/ijms21030776. I.F. = 4.183

6. Lazzarino G, Amorini AM, Signoretti S, Musumeci G, Lazzarino G, Caruso G, Pastore FS, Di Pietro V, Tavazzi B, Belli A. Pyruvate Dehydrogenase and Tricarboxylic Acid Cycle Enzymes Are Sensitive Targets of Traumatic Brain Injury Induced Metabolic Derangement. Int J Mol Sci. 2019;20(22). doi: 10.3390/ijms20225774. I.F. = 4.183

7. Caruso G, Fresta CG, Fidilio A, O'Donnell F, Musso N, Lazzarino G, Grasso M, Amorini AM, Tascedda F, Bucolo C, Drago F, Tavazzi B, Lazzarino G, Lunte SM, Caraci F. Carnosine Decreases PMA-Induced Oxidative Stress and Inflammation in Murine Macrophages. Antioxidants (Basel). 2019 Aug 6;8(8). pii: E281. doi: 10.3390/antiox8080281. I.F. = 4.504

8. Caruso G, Fresta CG, Grasso M, Santangelo R, Lazzarino G, Lunte SM, Caraci F. Inflammation as the common biological link between depression and cardiovascular diseases: Can carnosine exert a protective role? Curr Med Chem. 2019 doi: 10.2174/0929867326666190712091515. I.F. = 3.894

9. Musumeci G, Ravalli S, Amorini AM, Lazzarino G. Concussion in sports. J Funct Morphol Kinesiol. 2019; 4, 37; doi:10.3390/jfmk4020037.

10. Yakoub KM, Lazzarino G, Amorin AM, Caruso G, Scazzone C, Ciaccio M, Tavazzi B, Lazzarino G, Belli A, Di Pietro V. Fructose-1,6-Bisphosphate Protects Hippocampal Rat Slices from NMDA Excitotoxicity. Int J Mol Sci. 2019; 20, 2239; doi:10.3390/ijms20092239. I.F. = 3.878

11. Lazzarino G, Listorti I, Bilotta G, Capozzolo T, Amorini AM, Longo S, Caruso G, Lazzarino G, Tavazzi B, Bilotta P. Water- and Fat-Soluble Antioxidants in Human Seminal Plasma and Serum of Fertile Males. Antioxidants (Basel). 2019 Apr 11;8(4). pii: E96. doi: 10.3390/antiox8040096. I.F. = 4.504

12. Caruso G, Fresta CG, Musso N, Giambirtone M, Grasso M, Spampinato SF, Merlo S, Drago F, Lazzarino G, Sortino MA, Lunte SM, Caraci F. Carnosine Prevents Aβ-Induced Oxidative Stress and Inflammation in Microglial Cells: A Key Role of TGF-β1. Cells. 2019; doi: 10.3390/cells8010064. I.F. = 4.829

13. Caruso G, Fresta CG, Lazzarino G, Distefano DA, Parlascino P, Lunte SM, Lazzarino G, Caraci F. Sub-Toxic Human Amylin Fragment Concentrations Promote the Survival and Proliferation of SH-SY5Y Cells via the Release of VEGF and HspB5 from Endothelial RBE4 Cells. Int J Mol Sci. 2018; doi: 10.3390/ijms19113659. I.F. = 3.878

14. Lazzarino G, Listorti I, Muzii L, Amorini AM, Longo S, Di Stasio E, Caruso G, D’Urso S, Puglia I, Pisani G, Lazzarino G, Tavazzi B, Bilotta P. Low molecular weight compounds in human seminal plasma as potential biomarkers of male infertility. Hum Repr. 2018;33:1817-1828. I.F. = 4.990

15. Fresta CG, Chakraborty A, Wijesinghe MB, Amorini AM, Lazzarino G, Lazzarino G, Tavazzi B, Lunte SM, Caraci F, Dhar P, Caruso G. Non-toxic engineered carbon nanodiamond concentrations induce oxidative/nitrosative stress, imbalance of energy metabolism, and mitochondrial dysfunction in microglial and alveolar basal epithelial cells. Cell Death Dis. 2018;9:245. doi: 10.1038/s41419-018-0280-z. I.F. = 5.965

16. Lazzarino G, Longo S, Amorini AM, Di Pietro V, D'Urso S, Lazzarino G, Belli A, Tavazzi B. Single-step preparation of selected biological fluids for the high performance liquid chromatographic analysis of fat-soluble vitamins and antioxidants. J Chromatogr A. 2017;1527:43-52. I.F. = 3.981

17. Lazzarino G, Amorini AM, Petzold A, Gasperini C, Ruggieri S, Quartuccio ME, Lazzarino G, Di Stasio E, Tavazzi B. Serum Compounds of Energy Metabolism Impairment Are Related to Disability, Disease Course and Neuroimaging in Multiple Sclerosis. Mol Neurobiol. 2017;54:7520-7533 I.F. = 5.397

18. Di Pietro V, Lazzarino G, Amorini AM, Signoretti S, Hill LJ, Porto E, Tavazzi B, Lazzarino G, Belli A. Fusion or Fission: The Destiny of Mitochondria In Traumatic Brain Injury of Different Severities. Sci Rep. 2017;7(1):9189. doi: 10.1038/s41598-017-09587-2. I.F. = 4.259

19. Caruso G, Fresta CG, Martinez-Becerra F, Antonio L, Johnson RT, de Campos RP, Siegel JM, Wijesinghe MB, Lazzarino G, Lunte SM. Carnosine modulates nitric oxide in stimulated murine RAW 264.7 macrophages. Mol Cell Biochem. 2017;431:197-210.. I.F. = 2.699

20. Caruso G, Distefano DA, Parlascino P, Fresta CG, Lazzarino G, Lunte SM, Nicoletti VG. Receptor-mediated toxicity of human amylin fragment aggregated by short- and long-term incubations with copper ions. Mol Cell Biochem. 2017;425:85-93. I.F. = 2.699

21. Fresta CG, Hogard ML, Caruso G, Melo Costa,EE, Lazzarino G, Lunte SM. Monitoring carnosine uptake by RAW 264.7 macrophage cells using microchip electrophoresis with fluorescence detection. Anal Met 2017;9:402-408. I.F. = 1.900

22. Amorini AM, Lazzarino G, Di Pietro V, Signoretti S, Lazzarino G, Belli A, Tavazzi B. Severity of experimental traumatic brain injury modulates changes in concentrations of cerebral free amino acids. J Cell Mol Med. 2017;21:530-542. I.F. = 4.938

23. Barbagallo I, Vanella L, Distefano A, Nicolosi D, Maravigna A, Lazzarino G, Di Rosa M, Tibullo D, Acquaviva R, Li Volti G. Moringa oleifera Lam. improves lipid metabolism during adipogenic differentiation of human stem cells. Eur Rev Med Pharmacol Sci. 2016;20:5223-5232. I.F. = 1.778

24. Amorini AM, Lazzarino G, Di Pietro V, Signoretti S, Lazzarino G, Belli A, Tavazzi B. Metabolic, enzymatic and gene involvement in cerebral glucose dysmetabolism after traumatic brain injury. Biochim Biophys Acta Mol Basis of Dis. 2016;1862:679-687. I.F. = 4.882

25. Petzold A, Nijland PG, Balk LJ, Amorini AM, Lazzarino G, Wattjes MP, Gasperini C, van der Valk P, Tavazzi B, Lazzarino G, van Horssen J. Visual pathway neurodegeneration winged by mitochondrial dysfunction. Ann Clin Transl Neurol. 2015;2:140-150. I.F. = 4.656

26. Alberghina D, Piccione G, Amorini AM; Lazzarino G, Congiu F, Lazzarino G, Tavazzi B. Body temperature and plasma nitric oxid metabolites in response to standardized exercise test in the athletic horse. J Eq Vet Sci. 2015; doi/10.1016/j.jevs.2015.06.021. I.F. = 0.871

27. Di Pietro V, Amorini AM, Lazzarino G, Yakoub KM, D'Urso S, Lazzarino G, Belli A. S100B and Glial Fibrillary Acidic Protein as Indexes to Monitor Damage Severity in an In Vitro Model of Traumatic Brain Injury. Neurochem Res. 2015;40:991-999. I.F. = 2.593

28. Di Pietro V, Lazzarino G, Amorini AM, Tavazzi B, D'Urso S, Longo S, Vagnozzi R, Signoretti S, Clementi E, Giardina B, Lazzarino G, Belli A. Neuroglobin expression and oxidant/antioxidant balance after graded traumatic brain injury in the rat. Free Radic Biol Med. 2014;69:258-264. I.F. = 5.736

29. Signoretti S, Tavazzi B, Lazzarino G, Vagnozzi R. The relevance of assessing cerebral metabolic recovery for a safe return to play following concussion. In: SM Slobounov, WJ Sebastianelli (eds.) Concussions in Athletics From Brain to Behaviour. 2014; p. 89-112, New York, Springer.

30. Amorini AM, Nociti V, Petzold A, Gasperini C, Quartuccio E, Lazzarino G, Di Pietro V, Belli A, Signoretti S, Vagnozzi R, Lazzarino G, Tavazzi B. Serum lactate as a novel potential biomarker in multiple sclerosis. Biochim Biophys Acta Mol Basis of Dis. 2014;1842:,1137-1143. I.F. = 4.882

31. Slobounov S, Bazarian J, Bigler E, Cantu R, Hallett M, Harbaugh R, Hovda D, Mayer AR, Nuwer MR, Kou Z, Lazzarino G, Papa L, Vagnozzi R. Sports-related concussion: ongoing debate. British J Sports Med. 2014;48:75-76. I.F. = 5.025

32. Di Pietro V, Amorini AM, Tavazzi B, Vagnozzi R, Logan A, Lazzarino G, Signoretti S, Lazzarino G, Belli A. The molecular mechanisms affecting N-acetylaspartate homeostasis following experimental graded traumatic brain injury. Mol Med. 2014;20:147-157. I.F. = 4.508

33. Vagnozzi R, Signoretti S, Floris R, Marziali S, Manara M, Amorini AM, Belli A, Di Pietro V, D’Urso S, Pastore FS, Lazzarino G, Tavazzi B. Decrease in n-acetylaspartate following concussion may be coupled to decrease in creatine. J Head Trauma Rehabil. 2013;28:284-292. I.F. = 2.920

34. Amorini AM, Tuttobene T, Tomasello FM, Biazzo F, Gullotta S, De Pinto V, Lazzarino G, Tavazzi B. Glucose ameliorates the metabolic profile and mitochondrial function of platelet concentrates during storage in autologous plasma. Blood Transfus. 2013;11:61-70. I.F. = 2.372

35. Di Pietro V, Amorini AM, Tavazzi B, Hovda DA, Signoretti S, Giza CC, Lazzarino G, Vagnozzi R, Lazzarino G, Belli A. Potentially neuroprotective gene modulation in an in vitro model of mild traumatic brain injury. Mol Cell Biochem. 2013;375:185-198. I.F. = 2.393

36. Verachia W, Lazzarino G, Niven B, Bremer PJ. The effect of holding live sea urchins (Evechinus chloroticus) in air prior to gonad removal on gonad adenine nucleotide profiles during storage at 4°C. Food Chem. 2013;141:841-846. I.F. = 3.391

37. Cao J, Vecoli C, Neglia D, Tavazzi B, Lazzarino G, Novelli M, Masiello P, Wang YT, Puri N, Paolocci N, L'abbate A, Abraham NG. Cobalt-Protoporphyrin Improves Heart Function by Blunting Oxidative Stress and Restoring NO Synthase Equilibrium in an Animal Model of Experimental Diabetes. Front Physiol. 2012;3:1-9.

38. Lazzarino G, Vagnozzi R, Signoretti S, Manara M, Floris R, Amorini AM, Ludovici A, Marziali S, McIntosh TK, Tavazzi B. The Importance of Restriction from Physical Activity in the Metabolic Recovery of Concussed Brain. In: Brain Injury - Pathogenesis, Monitoring, Recovery and Management. 2012; p. 501-522, Rijeka: InTech - Open Access Company.

39. Amorini AM, Giorlandino C, Longo S, D'Urso S, Mesoraca A, Santoro ML, Picardi M, Gullotta S, Cignini P, Lazzarino D, Lazzarino G, Tavazzi B. Metabolic profile of amniotic fluid as a biochemical tool to screen for inborn errors of metabolism and fetal anomalies. Mol Cell Biochem. 2012;359:205-216. I.F. = 2.393

40. Lazzarino G, Amorini AM, Di Pietro V, Tavazzi B. HPLC analysis for the clinical-biochemical diagnosis of inborn errors of metabolism of purines and pyrimidines. Methods Mol Biol. 2011;708:99-117.

41. Tavazzi B, Batocchi AP, Amorini AM, Nociti V, D'Urso S, Longo S, Gullotta S, Picardi M, Lazzarino G. Serum metabolic profile in multiple sclerosis patients. Mult Scler Int. 2011;2011:1-8. doi: 10.1155/2011/167156.

42. Cozzolino M, Augello B, Carella M, Palumbo O, Tavazzi B, Amorini AM, Lazzarino G, Merla G, Brunetti-Pierri N. Chromosomal 17p13.3 microdeletion unmasking recessive Canavan disease mutation. Mol Gen Metab. 2011;104:706-707. I.F. = 2.625

43. Alberghina D, Piccione G, Amorini AM, D'Urso S, Longo S, Picardi M, Tavazzi B, Lazzarino G Modulation of circulating purines and pyrimidines by physical exercise in the horse. Eur J Appl Physiol. 2011;111:549-556. I.F. = 2.187

44. Alberghina D, Amorini AM, Lazzarino G. Modulation of peripheral markers of the serotoninergic system in healthy horses. Res Vet Sci. 2011;90:392-395. I.F. = 1.409

45. Signoretti S, Vagnozzi R, Tavazzi B, Lazzarino G. The Pathophysiology of Concussion. PM R. 2011;3(Suppl-2):S359-S368. I.F. = 1.534

46. Vagnozzi R, Signoretti S, Cristofori L, Alessandrini F, Floris R, Isgrò E, Ria A, Marziale S, Zoccatelli G, Tavazzi B, Del Bolgia F, Sorge R, Broglio SP, Mcintosh TK, Lazzarino G. Assessment of metabolic brain damage and recovery following mild traumatic brain injury: a multicentre, proton magnetic resonance spectroscopic study in concussed patients. Brain. 2010;133:3232-3242. I.F. = 9.186

47. Signoretti S, Vagnozzi R, Tavazzi B, Lazzarino G. Biochemical and neurochemical sequelae following mild traumatic brain injury: summary of experimental data and clinical implications. Neurosurg Focus. 2010; 29(5):1-12. doi: 10.3171/2010.9.FOCUS10183. I.F. = 2.105

48. Lazzarino G, Amorini AM, Eikelenboom M, Killestein J, Belli A, Di Pietro V, Tavazzi B, Barkhof F, Polman C, Uitdehaag B, Petzold A. Cerebrospinal fluid ATP metabolites in multiple sclerosis. Mult Scler J. 2010;16:549-554. I.F. = 4.822

49. Broglio SP, Vagnozzi R, Sabin M, Signoretti S, Tavazzi B, Lazzarino G. Concussion occurrence and knowledge in Italian football (soccer). J Sports Sci Med. 2010;9:418-430. I.F. = 1.025

50. Di Pietro V, Amin D, Pernagallo S, Lazzarino G, Tavazzi B, Vagnozzi R, Pringle A, Belli A. Transcriptomics of traumatic brain injury: gene expression and molecular pathways of different grades of insult in a rat organotypic hippocampal culture model. J Neurotrauma. 2010;27:349-359. I.F. = 3.714

51. Signoretti S, Di Pietro V, Vagnozzi R, Lazzarino G, Amorini AM, Belli A, D'urso S, Tavazzi B. Transient alterations of creatine, creatine phosphate, N-acetylaspartate and high-energy phosphates after mild traumatic brain injury in the rat. Mol Cell Biochem. 2010;333:269-277. I.F. = 2.393

52. Capuani S, Gili T, Bozzali M, Russo S, Porcari P, Cametti C, Muolo M, D'amore E, Maraviglia B, Lazzarino G, Pastore FS. Boronophenylalanine uptake in C6 glioma model is dramatically increased by L-DOPA preloading. Appl Radiat Isot. 2009;67:S34-S36. I.F. = 1.231

53. Amorini AM, Petzold A, Tavazzi B, Eikelenboom J, Keir G, Belli A, Giovannoni G, Di Pietro V, Polman C, D'urso S, Vagnozzi R, Uitdehaag B, Lazzarino G. Increase of uric acid and purine compounds in biological fluids of multiple sclerosis patients. Clin Biochem. 2009;42:1001-1006. I.F. = 2.275

54. Vagnozzi R, Signoretti S, Tavazzi B, Floris R, Ludovici A, Marziali S. Tarascio G, Amorini AM, Di Pietro V, Delfini R, Lazzarino G. Temporal window of metabolic brain vulnerability to concussions: a pilot 1H-MRS study in concussed athletes – part III. Neurosurgery. 2008;62:1286-1296. I.F. = 3.620

55. Perruzza I, Di Pietro V, Tavazzi B, Lazzarino G, Gamberini M, Barsotti P, Amorini AM, Giardina B, Balducci A. Is adenine phosphoribosyltransferase deficiency a still underdiagnosed cause of urolithiasis and chronic renal failure? A report of two cases in a family with an uncommon novel mutation. NTD Plus. 2008;1-4. doi:10.1093/ndtplus/sfn072.

56. Capuani S, Gili T, Bozzali M, Russo S, Porcari P, Cametti C, D'Amore E, Colasanti M, Venturini G, Maraviglia B, Lazzarino G, Pastore FS. L-DOPA preloading increases the uptake of borophenylalanine in C6 glioma rat model: a new strategy to improve BNCT efficacy. Int J Radiat Oncol Biol Phys. 2008;72:562-567.
I.F. = 4.258

57. Kaludercic N, Lindsey ML, Tavazzi B, Lazzarino G, Paolocci N. Inhibiting metalloproteases with PD 166793 in heart failure: impact on cardiac remodeling and beyond. Cardiovasc Ther. 2008;26:1-14.
I.F. = 2.362

58. Moens AL, Champion HC, Clayes MJ, Tavazzi B, Kaminski PM, Borgonjon DJ, Van Nassauw L, Zyiman M, Bedja D, Wuyts FL, Elsaesser RS, Cos P, Gabrielso KL, Lazzarino G, Paolocci N, Timmermans JP, Vrints CJ, Kass D. High-dose folic acid pretreatment blunts cardiac dysfunction during ischemia coupled to maintenance of high-energy phosphates and reduces postreperfusion injury. Circulation. 2008;117:1810-1819. I.F. = 14.430

59. Di Pietro V, Gambacurta A, Amorini AM, Finocchiaro A, D’Urso S, Ceccarelli L, Tavazzi B, Giardina B, Lazzarino G. A new T677C mutation of the aspartoacylase gene encodes for a protein with no enzymatic activity. Clin Biochem. 2008;41:611-615. I.F. = 2.275

60. Bellia F, Amorini AM, La Mendola D, Vecchio G, Tavazzi B, Giardina B, Di Pietro V, Lazzarino G, Rizzarelli E. New glycosidic derivatives of histidine-containing dipeptides with antioxidant properties and resistant to carnosinase activity. Eur J Med Chem. 2008;43:373-380. I.F. = 3.447

61. Amorini AM, Tuttobene M, Lazzarino G, Denti G. Evaluation of biochemical parameters in platelet concentrates stored in glucose solution. Blood Transfus. 2007;5:24-32. I.F. = 2.372

62. Tavazzi B, Vagnozzi R, Signoretti S, Amorini AM, Belli A, Cimatti M, Delfini R, Di Pietro V, Finocchiaro A, Lazzarino G. Temporal window of metabolic brain vulnerability to concussions: oxidative and nitrosative stresses-part II. Neurosurgery. 2007;61:390-395. I.F. = 3.620

63. Vagnozzi R, Tavazzi B, Signoretti S, Amorini AM, Belli A, Cimatti M, Delfini R, Di Pietro V, Finocchiaro A, Lazzarino G. Temporal window of metabolic brain vulnerability to concussions: mitochondrial-related impairment-part I. Neurosurgery. 2007;61:379-388. I.F. = 3.620

64. Amorini AM, Bellia F, Di Pietro V, Giardina B, La Mendola D, Lazzarino G, Sortino S, Tavazzi B, Rizzarelli E, Vecchio G. Synthesis and antioxidant activity of new homocarnosine beta-cyclodextrin conjugates. Eur J Med Chem. 2007;42:910-920. I.F. = 3.447

65. Romitelli F, Santini FA, Chierici E, Pitocco D, Tavazzi B, Amorini AM, Lazzarino G, Di Stasio E. Comparison of nitrite/nitrate concentration in human plasma and serum samples measured by the enzymatic batch Griess assay, ion-pairing HPLC and ion-trap GC-MS: The importance of a correct removal of proteins in the Griess assay. J Chromatogr B Analyt Technol Biomed Life Sci. 2007;851:257-267. I.F. = 2.729

66. Di Pietro V, Perruzza I, Amorini AM, Balducci A, Ceccarelli L, Lazzarino G, Barsotti P, Giardina B, Tavazzi B. Clinical, biochemical and molecular diagnosis of a compound homozygote for the 254 bp deletion-8 bp insertion of the APRT gene suffering from severe renal failure. Clin Biochem. 2007;40:73-80. I.F. = 2.275

67. Donzelli S, Switzer CH, Thomas DD, Ridnour LA, Espey MG, Isenberg JS, Tocchetti CG, King SB, Lazzarino G, Miranda KM, Roberts DD, Feelisch M, Wink DA. The activation of metabolites of nitric oxide synthase by metals is both redox and oxygen dependent: a new feature of nitrogen oxide signaling. Antioxid Redox Signal 2006;8:1363-1371. I.F. = 7.407

68. Donzelli S, Espey MG, Thomas DD, Mancardi D, Tocchetti CG, Ridnour LA, Paolocci N, King SB, Miranda KM, Lazzarino, G, Fukuto JM, Wink DA. Discriminating formation of HNO from other reactive nitrogen oxide species. Free Radic Biol Med. 2006;40:1056-1066. I.F. = 5.736

69. Paolocci N, Tavazzi B, Biondi R, Gluzband YA, Amorini AM, Tocchetti CG, Hejazi M, Caturegli PM, Kajstura J, Lazzarino G, Kass DA. Metalloproteinase inhibitor counters high-energy phosphate depletion and AMP deaminase activity enhancing ventricular diastolic compliance in subacute heart failure. J Pharmacol Exp Ther. 2006;317:506-513. I.F. = 3.972

70. Belli A, Sen J, Petzold A, Russo S, Kitchen N, Smith M, Tavazzi B, Vagnozzi R, Signoretti S, Amorini AM, Bellia F, Lazzarino G. Extracellular N-acetylaspartate depletion in traumatic brain injury. J Neurochem. 2006;96:861-869. I.F. = 4.281

71. Tavazzi B, Lazzarino G, Leone P, Amorini AM, Bellia F, Janson CG, Di Pietro V, Ceccarelli L, Donzelli S, Francis JS, Giardina B. Simultaneous high performance liquid chromatographic separation of purines, pyrimidines, N-acetylated amino acids, and dicarboxylic acids for the chemical diagnosis of inborn errors of metabolism. Clin Biochem. 2005;38:997-1008. I.F. = 2.275

72. Vagnozzi R, Signoretti S, Tavazzi B, Cimatti M, Amorini AM, Donzelli S, Delfini R, Lazzarino G. Hypothesis of the post-concussive vulnerable brain: experimental evidence of its metabolic occurrence. Neurosurgery. 2005;57:164-171. I.F. = 3.620

73. Takimoto E, Champion HC., LM, Ren S, Rodriguez ER, Tavazzi B, Lazzarino G, Paolocci N, Wang Y, Kass DA.. Oxidant stress from nitric oxide synthase-3 uncoupling plays major role in pathologic remodeling to pressure-load cardiac hypertrophy. J Clin Invest. 2005;115:1221-1231. I.F. = 13.215

74. Tavazzi B, Signoretti S, Lazzarino G, Amorini AM, Delfini R, Cimatti M, Marmarou A, Vagnozzi R. Cerebral oxidative stress and depression of energy metabolism correlate with severity of diffuse brain injury in rats. Neurosurgery. 2005;56:582-589. I.F. = 3.620

75. Cristofori L, Tavazzi B, Gambin R, Vagnozzi R, Signoretti S, Amorini AM, Fazzina G, Lazzarino G. Biochemical analysis of the cerebrospinal fluid: evidence for catastrophic energy failure and oxidative damage preceding brain death in severe head injury: a case report. Clin Biochem. 2005;38:97-100. I.F. = 2.275

76. Signoretti S, Marmarou A, Tavazzi B, Dunbar J, Amorini AM, Lazzarino G, Vagnozzi R. The protective effect of cyclosporin A upon N-acetylaspartate and mitochondrial dysfunction following experimental diffuse traumatic brain injury. J Neurotrauma. 2004;21:1154-1167. I.F. = 3.714

77. Serafino A, Sinibaldi-Vallebona P, Lazzarino G, Tavazzi B, Rasi G, Pierimarchi P, Andreola F, Moroni G, Galvano G, Galvano F, Garaci E. Differentiation of human melanoma cells induced by cyanidin-3-O-beta-glucopyranoside. FASEB J. 2004;18:1940-1952. I.F. = 5.043

78. Galvano F, La Fauci FL, Lazzarino G, Fogliano V, Ritieni A, Cappellano S, Battistini NC, Tavazzi B, Galvano G. Cyanidins: metabolism and biological properties. J Nutr Biochem. 2004;15:2-11. I.F. = 3.794

79. Lazzarino G, Amorini AM, Fazzina G, Vagnozzi R, Signoretti S, Donzelli S, Di Stasio E, Giardina B, Tavazzi B. Single-sample preparation for simultaneous cellular redox and energy state determination. Anal Biochem. 2003;322:51-59. I.F. = 2.219

80. Amorini AM, Fazzina G, Lazzarino G, Tavazzi B, Galvano F, Galvano G. Cyanidin-3-O--glucopyranoside protects myocardium and erythrocytes from oxygen radical-mediated damages. Free Radic Res. 2003;37:453-460. I.F. = 2.975

81. Tavazzi B, Amorini AM, Fazzina G, Di Pierro D, Tuttobene M, Giardina B, Lazzarino G. Oxidative stress induces impairment of human erythrocyte energy metabolism through the oxygen radical-mediated direct activation of AMP-deaminase J Biol Chem. 2001;276:48083-48092. I.F. = 4.573

82. Amorini AM, Fazzina G, Lazzarino G, Tavazzi B, Di Pierro D, Santucci R, Sinibaldi F, Galvano F, Galvano G. Activity and mechanism of the antioxidant properties of cyanidin-3-O-β-glucopyranoside. Free Radic Res. 2001;35:951-964. I.F. = 2.975

83. Hardin CD, Lazzarino G, Tavazzi B, Di Pierro D, Roberts TM, Giardina B, Rovetto MJ. Myocardial Metabolism of exogenous fructose-1,6-bisphosphate is consistent with transport by a dicarboxylate transporter. Am J Physiol Heart Circ Physiol. 2001;281:H2654-H2660. I.F. = 3.838

84. Signoretti S, Marmarou A, Tavazzi B, Lazzarino G, Beaumont A, Vagnozzi R. N-Acetylaspartate reduction as a measure of injury severity and mitochondrial dysfunction following diffuse traumatic brain injury. J Neurotrauma. 2001;18: 977-993. I.F. = 3.714

85. Cristofori L, Tavazzi B, Gambin R, Vagnozzi R, Vivenza C, Amorini AM, Di Pierro D, Fazzina G, Lazzarino G. Early onset of lipid peroxidation after human traumatic brain injury: a fatal limitation for the free radical scavenger pharmacological therapy? J Investig Med. 2001;49:450-458. I.F. = 1.688

86. Lazzarino G, Tavazzi B, Sinibaldi-Vallebona P, Di Pierro D, Rasi G. Effectiveness of a new device to retain carcinogenic compounds of tar from mainstream cigarette smoke for the prevention of smoking-associated tumors. Anticancer Res. 2001;21:887-892. I.F. = 1.826

87. Serafino AL, Sinibaldi-Vallebona P, Lazzarino G, Tavazzi B, Di Pierro D, Rasi G, Ravagnan G. Modifications of mitochondria in human tumor cells during anthracycline-induced apoptosis. Anticancer Res. 2000;20:3383-3394. I.F. = 1.826

88. Di Pierro D, Lazzarino G, Pastore FS, Tavazzi B, Del Bolgia F, Amorini AM, Fazzina G, Giuffrè R. Determination of boronophenylalanine in biological samples using precolumn ortophtalaldehyde derivatization and reversed phase high-performance liquid chromatography. Anal Biochem. 2000;284:301-306. I.F. = 2.219

89. Tavazzi B, Di Pierro D, Amorini AM, Fazzina G, Giardina B, Lazzarino G. Energy metabolism and lipid peroxidation of human erythrocytes as a function of increased oxygen radical production. Eur J Biochem. 2000;267:684-689. I.F. = 4.001

90. Tavazzi B, Di Pierro D, Amorini AM, Galvano M, Fazzina G, Giardina B, Lazzarino G. NAD(P)H hydrolysis into ADP-ribose(P) and nicotinamide induced by reactive oxygen species: a new mechanism of oxygen radical toxicity. Free Radic Res. 2000;33:1-12. I.F. = 2.975

91. Tavazzi B, Vagnozzi R, Di Pierro D, Amorini AM, Fazzina G, Signoretti S, Marmarou A, Caruso I, Lazzarino G. Ion-pairing high-performance liquid chromatographic method for the detection of N-acetylaspartate and N-acetylglutamate in cerebral tissue extracts. Anal Biochem. 2000;277:104-108. I.F. = 2.219

92. Vagnozzi R, Marmarou A, Tavazzi B, Signoretti S, Di Pierro D, Del Bolgia F, Amorini AM, Fazzina G, Giuffrè R, Lazzarino G. Changes of cerebral energy metabolism and lipid peroxidation in rats leading to mitochondrial dysfunction after diffuse brain injury. J Neurotrauma. 1999:16:903-913. I.F. = 3.714

93. Di Francesco P, Tavazzi B, Gaziano R, Lazzarino G, Casalinuovo IA, Di Pierro D, Garaci E. Differential effects of acute morphine administrations on polymorphonuclear cell metabolism in various mouse strains. Life Sci. 1998;63:2167-2174. I.F. = 2.702

94. Tavazzi B, Di Pierro D, Bartolini M, Marino M, Distefano S, Galvano M, Villani C, Giardina B, Lazzarino G. Lipid peroxidation, tissue necrosis, and metabolic and mechanical recovery of isolated reperfused rat heart as a function of increasing ischemia. Free Radic Res. 1998;28:25-37. I.F. = 2.975

95. Vagnozzi R, Tavazzi B, Di Pierro D, Giardina B, Fraioli B, Signoretti S, Distefano S, Galvano M, Lazzarino G. Effects of increasing times of incomplete cerebral ischemia upon the energy state and lipid peroxidation in the rat. Exp Brain Res. 1997;117:411-418. I.F. = 2.036

96. Perno CF, Santoro N, Balestra E, Aquaro S, Lazzarino G, Di Pierro D, Tavazzi B, Balzarini J, Garaci E, Grimaldi S, Caliò R. Red-blood cells mediated delivery of 9-(2-phosphonylmethoxyethyl)adenine to primary macrophages: efficiency, metabolism, and activity against human immunodeficiency virus or herpes simplex virus. Antiviral Res. 1997;33:153-164. I.F. = 3.938

97. Siragusa P, Tavazzi B, Lazzarino G, Di Pierro D, Belli A, Amorini AM, Giuffrè R, Vagnozzi R. Experimental model of asymmetric brain ischemia and reperfusion in the rat. J Neurosurgic Sci. 1997;41:249-255.

98. Di Pierro D, Tavazzi B, Lazzarino G, Galvano M, Bartolini M, Giardina B. Separation of representative lipid compounds of biological membranes and lipid derivatives from peroxidized polyunsaturated fatty acids by reverse phase high-performance liquid chromatography. Free Radic Res. 1997;26:307-317. I.F. = 2.975

99. Perno CF, Balestra E, Aquaro S, Panti S, Cenci A, Lazzarino G, Tavazzi B, Di Pierro D, Balzarini J, Caliò R. Potent inhibition of human immunodeficiency virus and herpes simplex virus type 1 by 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in primary macrophages is determined by drug metabolism, nucleotide pools and cytokines. Mol Pharmacol. 1996;50:11-19. I.F. = 4.128

100. Di Pierro D, Tavazzi B, Perno CF, Bartolini M, Balestra E, Caliò R, Giardina B, Lazzarino G. An ion-pairing high-performance liquid chromatographic method for the direct simultaneous determination of nucleotides, deoxynucleotides, nicotinic coenzymes, oxypurines, nucleosides, and bases in perchloric acid cell extracts. Anal Biochem. 1995;231:407-412. I.F. = 2.219

101. Vagnozzi R, Lazzarino G, Tavazzi B, Di Pierro D, Siragusa P, Giuffrè R, Giardina B. Incomplete cerebral ischemia in the rat provokes increase of tissue and plasma malondialdehyde. Biol Trace Elem Res. 1995;47:241-246. I.F. = 1.748

102. Lazzarino G, Tavazzi B, Di Pierro D, Vagnozzi R, Penco M, Giardina B. The relevance of malondialdehyde as a biochemical index of lipid peroxidation of post-ischemic tissues in the rat and human beings. Biol Trace Elem Res. 1995;47:165-170. I.F. = 1.748

103. Vagnozzi R, Tavazzi B, Lazzarino G, Di Pierro D, Siragusa P, Giuffrè R, Giardina B. Time dependence of plasma malondialdehyde, oxypurines and nucleosides during incomplete cerebral ischemia in the rat. Biochem Med Metabol Biol. 1994;53:948-954.

104. Lazzarino G, Raatikainen P, Nuutinen M, Nissinen J, Tavazzi B, Di Pierro D, Giardina B, Peuhkurinen K. Myocardial release of malondialdehyde and purine compounds during coronary bypass surgery. Circulation. 1994;90:291-297. I.F. = 14.430

105. Vagnozzi R, Lazzarino G, Tavazzi B, Di Pierro D, Rosa G, Pastore FS, Siragusa P, Giuffrè R, Giardina B. Increased oxidative stress induced by reduction of CPP. Minerva Anestesiol. 1993;59:751-754. I.F. = 2.134

106. Giardina B, Penco M, Lazzarino G, Romano S, Tavazzi B, Fedele F, Di Pierro D, Dagianti A. Effectiveness of thrombolysis is associated with a time dependent elevation of malondialdehyde in peripheral blood of patients with acute myocardial infarction. Am J Cardiol. 1993;10: 788-793. I.F. = 3.276

107. Lazzarino G, Vagnozzi R, Tavazzi B, Pastore FS, Di Pierro D, Siragusa P, Belli A, Giuffrè R, Giardina B. MDA, oxypurines and nucleosides relate to reperfusion in short-term incomplete cerebral ischemia in the rat. Free Radic Biol Med. 1992;13:489-498. I.F. = 5.736

108. Di Pierro D, Tavazzi B, Lazzarino G, Giardina B. Malondialdehyde is a biochemical marker of peroxidative damage in the isolated reperfused rat heart. Mol Cell Biochem. 1992;116:193-196. I.F. = 2.393

109. Tavazzi B, Starnes JW, Lazzarino G, Di Pierro D, Nuutinen M, Giardina B. Exogenous fructose-1,6-bisphosphate is a metabolizable substrate for the isolated normoxic rat heart. Basic Res Cardiol. 1992;87:280-289. I.F. = 5.414

110. Lazzarino G, Tavazzi B, Di Pierro D, Giardina B. Ischemia and reperfusion: effect of fructose-1,6-bisphosphate. Free Radic Res Comms. 1992;16:325-339. I.F. = 2.975

111. Tavazzi B, Lazzarino G, Di Pierro D, Giardina B. Malondialdehyde production and ascorbate decrease are associated to the reperfusion of the isolated post-ischemic rat heart. Free Radic Biol Med. 1992;13:75-79. I.F. = 5.736

112. Starnes JW, Seiler KS, Bowles DK, Giardina B, Lazzarino G. Fructose-1,6-bisphosphate improves efficiency of work in isolated perfused rat hearts. Am J Physiol. 1992;262:H380-H384. I.F. = 3.838

113. Lazzarino G, Di Pierro D, Tavazzi B, Cerroni L, Giardina B. Simultaneous separation of malondialdehyde, ascorbic acid, and adenine nucleotide derivatives from biological samples by ion-pairing high-performance liquid chromatography. Anal Biochem. 1991;197:191-196. I.F. = 2.219

114. Nuutinen M, Lazzarino G, Giardina B, Hassinen IE. Effect of exogenous fructose-1,6-bisphosphate on glycolysis in the isolated perfused rat heart. Am Heart J 1991;122:523-527. I.F. = 4.463

115. Hassinen IE, Nuutinen M, Ito K, Nioka S, Lazzarino G, Giardina B, Chance B. Mechanism of the effect of exogenous fructose-1,6-bisphosphate on myocardial energy metabolism. Circulation. 1991;83:584-593. I.F. = 14.430

116. Lazzarino G, Tavazzi B, Nuutinen M, Cerroni L, Di Pierro D, Giardina B. Preserving effect of fructose-1,6-bisphosphate on high-energy phosphate compounds during anoxia and reperfusion in isolated Langendorff-perfused rat hearts. J Mol Cell Cardiol. 1991;23:13-23. I.F. = 4.655

117. Scatena R, Marini S, Tavazzi B, Lazzarino G, Giardina B. Peripheral blood lymphocytes activation: sterol metabolism and LDL receptor. Clin Chem Enzymol Comms. 1990;3:73-79.

118. Tavazzi B, Cerroni L, Di Pierro D, Lazzarino G, Nuutinen M, Starnes JW, Giardina B. Oxygen radical injury and loss of high energy compounds in anoxic and reperfused rat heart: prevention by exogenous fructose-1,6-bisphosphate. Free Radic Res Comms. 1990;10:167-176. I.F. = 2.975

119. Brix O, Condò SG, Lazzarino G, Clementi E, Scatena R, Giardina B. Arctic life adaptation-III. The function of whale (Balaenoptera Acutorostrata) hemoglobin. Comp Biochem Physiol B. 1989;94:139-142. I.F. = 1.551

120. Lazzarino G, Nuutinen M, Tavazzi B, Di Pierro D, Giardina B. A method for preparing freeze-clamped tissue samples for metabolite analyses. Anal Biochem. 1989;181:239-241. I.F. = 2.219

121. Giardina B, Brix O, Nuutinen M, El Sherbini S, Bardgard A, Lazzarino G, Condò S.G. Arctic adaptation in reender: the energy saving of a haemoglobin. FEBS Letters. 1989;247:135-138. I.F. = 3.169

122. Condò SG, El-Sherbini S, Shehata YM, Serpe E, Nuutinen M, Lazzarino G, Giardina B. Regulation of the oxygen affinity of haemoglobin from the reindeer (Rangifer Tarandus Tarandus L.). Arctic Med Res. 1988;47:83-88.

123. Lazzarino G, Viola AR. Mulieri L, Rotilio G, Mavelli I. Prevention by fructose-1,6-bisphosphate of cardiac oxidative damage induced in mice by subchronic doxorubicin treatment. Cancer Res. 1987;47:6511-6516. I.F. = 9.329

124. Schinetti ML, Greco R, Lazzarino G, Bertelli A. Inhibiting effect of fructose-1,6-diphosphate on rat mast cell histamine release. Int J Tissue React. 1983;V:55-59.

125. Schinetti ML, Lazzarino G. Inhibition of phorbol ester-stimulated chemiluminescence and superoxide production in human neutrophils by fructose-1,6-diphosphate. Biochem Pharmacol. 1985;35:1762-1764. I.F. = 5.009

126. Cattani L, Costrini R, Lazzarino G, Diana M, Galzigna L. Fructose-1,6-diphosphate counteracts potassium effects on cardiac muscle. Pharmacol Res. 1984;16:785-793. I.F. = 4.408

127. Tarsi R, Ripa S, Simonetti N, Lazzarino G. Serum lysozyme increased by fructose-1,6-diphosphate in men, rabbits and mice. J Leukocyte Biol. 1984;35:459-465. I.F. = 4.289

128. Lazzarino G, Cattani L, Costrini R, Mulieri L, Candiani A, Galzigna L. Increase of intraerythrocytic fructose-1,6-diphosphate after incubation of whole human blood with fructose-1,6-diphosphate. Clin Biochem. 1984;17:42-45. I.F. = 2.275

129. Schinetti ML, Greco R, Lazzarino G, Soldani G, Bertelli A. Mast cell histamine release induced by doxorubicin and the inhibitory effect of fructose-1,6-diphosphate. Arzneimittel-Forsch./Drug Res. 1983;33:834-836. I.F. = 0.701