MALFA GIUSEPPE

Ricercatore a tempo determinato Legge 240/10

Orari di ricevimento

Mercoledì dalle ore 10:00 alle ore 11:00 Giovedì dalle ore 11:00 alle ore 12:00

Curriculum

Giuseppe Antonio Malfa 46 years old
Italian Current address:
Section of Biochemistry, Department of Drug Sciences, University of Catania, Italy.
Via A. Doria n° 6, 95125 Catania, Italy.
E-mail : g.malfa@unict.it
2008: Master's Degree in Chemistry and Pharmaceutical Sciences (University of Catania)
2010: Visiting Researcher at the Department of Physiology & Pharmacology, College of Medicine, University
of Toledo, Ohio U.S.A.
2011: Visiting Researcher at the Department of Biochemistry, University College of Cork, Ireland.
2014 : Ph.D in Neuroscience (University of Catania, University of Rome La Sapienza)
2014 : Assistant Professor of Biochemistry, University of Catania
2016: Professor of Plant and Animal Biology and Pharmaceutical Biology, University of Catania
Involved in the study of natural substances with antioxidant activity and their therapeutic use;
Characterization of biological activity and mechanisms of action of plant drugs and natural substances;
Characterization of biological activity and mechanisms of action of plant extracts in tumour cell lines and in
cellular models of metabolic pathologies; Identification of active ingredients in natural extracts;
Oxidative stress: in vitro and in vivo studies on free radical toxicity and on antioxidant defence mechanisms
in different biological systems and physio-pathological conditions;
Co-Leader of a Research Team on Natural Compounds at the Laboratory of Biochemistry (University of
Catania), involved in researches related to plant metabolites and cellular interactions focused on the anti-inflammatory response. Scientific Chief of 2 research projects regarding the potential effects of
nutraceuticals on the modulation of gut microbiota and adipogenesis.
Author of several scientific papers in referred journals, 3 chapters in international books as well as
Technical papers; invited speaker of International and World Congresses. Reviewer of several International
Scientific Journals: International Journal of Molecular Sciences, Natural Products Research, Evidence-Based
Complementary and Alternative Medicine, etc…1.
Tenuta Maria Concetta, Malfa Giuseppe Antonio, Bonesi Marco, Acquaviva Rosaria, Loizzo Monica
Rosa, Dugay Annabelle, Bouzidi Chouaha, Tomasello Barbara, Tundis Rosa, Deguin Brigitte. ‘LC-ESIQTOF-MS Profiling, Protective Effects on Oxidative Damage, and Inhibitory Activity of Enzymes
Linked to Type 2 Diabetes and Nitric Oxide Production of Vaccinium Corymbosum L. (Ericaceae)
Extracts’. 1 Jan. 2020 : 1 – 20
2. Natalizia Miceli, Emilia Cavò, Monica Ragusa, Francesco Cacciola, Luigi Mondello, Laura Dugo,
Rosaria Acquaviva, Giuseppe Antonio Malfa, Andreana Marino, Manuela D’Arrigo, Maria Fernanda
Taviano. Brassica incana Ten.(Brassicaceae): Phenolic Constituents, Antioxidant and Cytotoxic
Properties of the Leaf and Flowering Top Extracts. 2020.
3. Maria Concetta Tenuta, Brigitte Deguin, Monica Rosa Loizzo, Annabelle Dugay, Rosaria Acquaviva,
Giuseppe Antonio Malfa, Marco Bonesi, Chouaha Bouzidi, Rosa Tundis. Contribution of Flavonoids
and Iridoids to the Hypoglycaemic, Antioxidant, and Nitric Oxide (NO) Inhibitory Activities of Arbutus
unedo L. Antioxidants 9 (2), 184. 2020.
4. Maria Fernanda Taviano, Natalizia Miceli, Rosaria Acquaviva, Giuseppe Antonio Malfa, Salvatore
Ragusa, Deborah Giordano, Guillermo Cásedas, Francisco Les, Víctor López. Cytotoxic, Antioxidant,
and Enzyme Inhibitory Properties of the Traditional Medicinal Plant Matthiola incana (L.) R. Br.
Biology, 2020.
5. Giuseppa Castellino, Dragana Nikolic, Antonio Magán-Fernández, Giuseppe Antonio Malfa, Roberta
Chianetta, Angelo M. Patti, Antonella Amato, Giuseppe Montalto, Peter P. Toth, Maciej Banach,
Arrigo F. G. Cicero and Manfredi Rizzo. Altilix® supplement containing chlorogenic acid and luteolin
improved hepatic and cardiometabolic parameters in subjects with the metabolic syndrome: a 6-
month randomized, double-blind, placebo-controlled study. Nutrients 2019, 11.
6. Barbara Tomasello, Giuseppe Antonio Malfa, Alfonsina La Mantia, Natalizia Miceli, Giuseppe
Sferrazzo, Maria Fernanda Taviano, Claudia Di Giacomo, Marcella Renis, Rosaria Acquaviva.
Anti-adipogenic and anti-oxidant effects of a standardised extract of Moro blood oranges (Citrus
sinensis (L.) Osbeck) during adipocyte differentiation of 3T3-L1 preadipocytes. Natural Product
Research 2019-09, journal-article DOI 10.1080/14786419.2019.1660337
7. Rosaria Acquaviva, Floriana D’Angeli, Giuseppe Antonio Malfa, Simone Ronsisvalle, Adriana Garozzo,
Aldo Stivala, Salvatore Ragusa, Daria Nicolosi, Mario Salmeri, Carlo Genovese. Antibacterial and antibiofilm activities of walnut pellicle extract (Juglans regia L.) against coagulase-negative staphylococci.
Natural Product Research 2019-08, journal-article DOI 10.1080/14786419.2019.1650352.
8. Giuseppe Antonio Malfa, Barbara Tomasello, Rosaria Acquaviva, Carlo Genovese, Alfonsina La
Mantia, Francesco Paolo Cammarata, Monica Ragusa, Marcella Renis, Claudia Di Giacomo. Betula
etnensis Raf. (Betulaceae) Extract Induced HO-1 Expression and Ferroptosis Cell Death in Human
Colon Cancer Cells. International Journal of Molecular Sciences 2019-06, journal-article DOI:
10.3390/ijms20112723.
9. Carlo Genovese, Rosaria Acquaviva, Simone Ronsisvalle, Gianna Tempera, Giuseppe Antonio Malfa,
Floriana D’Angeli, Salvatore Ragusa, Daria Nicolosi. In vitro evaluation of biological activities of
Orobanche crenata Forssk. leaves extract. Natural Product Research 2019-01, journal-article DOI
10.1080/14786419.2018.1552697.
10. Rosaria Acquaviva, Carlo Genovese, Andrea Amodeo, Barbara Tomasello, Giuseppe Malfa, Valeria
Sorrenti, Gianna Tempera, Alessandro Paolo Addamo, Salvatore Ragusa, Tundis Rosa, Francesco
Menichini, Claudia Di Giacomo. Biological activities of Teucrium flavum L., Teucrium fruticans L., and
Teucrium siculum rafin crude extracts. Plant Biosystems 2018, journal-article DOI:
10.1080/11263504.2017.1330773.
11. Marco Bonesi, Monica R Loizzo, Rosaria Acquaviva, Giuseppe A Malfa, Francesca Aiello, Rosa Tundis.
Anti-inflammatory and antioxidant agents from Salvia genus (Lamiaceae): An assessment of the
current state of knowledge. Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry 2017,
journal-article DOI: 10.2174/1871523016666170502121419.
12. Barbara Tomasello, Giuseppe Antonio Malfa, Angela Strazzanti, Santi Gangi, Claudia Di Giacomo,
Francesco Basile, Marcella Renis. Effects of physical activity on systemic oxidative/DNA status in
breast cancer survivors. Oncology Letters 2017, journal-article DOI: 10.3892/ol.2016.5449.
13. Rosaria Acquaviva, Valeria Sorrenti, Rosa Santangelo, Venera Cardile, Barbara Tomasello, Giuseppe
Malfa, Luca Vanella, Andrea Amodeo, Carlo Genovese, Silvana Mastrojeni, Michela Pugliese, Monica
Ragusa, Claudia Di Giacomo. Effects of an extract of Celtis aetnensis (Tornab.) Strobl twigs on human
colon cancer cell cultures. Oncology Reports 2016, journal-article DOI: 10.3892/or.2016.5035.
14. Rosa Chillemi, Nunzio Cardullo, Valentina Greco, Giuseppe Malfa, Barbara Tomasello, Sebastiano
Sciuto. Synthesis of amphiphilic resveratrol lipoconjugates and evaluation of their anticancer activity
towards neuroblastoma SH-SY5Y cell line. European Journal of Medicinal Chemistry 2015, journalarticle DOI: 10.1016/j.ejmech.2015.04.038.
15. Giuseppe A Malfa, Barbara Tomasello, Fulvia Sinatra, Giusy Villaggio, Francesco Amenta, Roberto
Avola, Marcella Renis. "Reactive" response evaluation of primary human astrocytes after
methylmercury exposure. Journal of Neuroscience Research 2014, journal-article DOI:
10.1002/jnr.23290.
16. S Grasso, V Bramanti, D Tomassoni, D Bronzi, G Malfa, E Traini, M Napoli, M Renis, F Amenta, R
Avola.Effect of lipoic acid and α-glyceryl-phosphoryl-choline on astroglial cell proliferation and
differentiation in primary culture. Journal of Neuroscience Research2014, journal-article DOI:
10.1002/jnr.23289.
17. Giuseppe AP Cirrone, Daniele Margarone, Mario Maggiore, Antonello Anzalone, Marco Borghesi, S
Bijan Jia, Stepan S Bulanov, Sergei Bulanov, Massimo Carpinelli, Salvatore Cavallaro, Mariapompea
Cutroneo, Giacomo Cuttone, Marco Favetta, Santo Gammino, Ondrej Klimo, Lorenzo Manti, Georg
Korn, Giuseppe Malfa, Jiri Limpouch, Agatino Musumarra, Ivan Petrovic, Jan Prokupek, Jan Psikal,
Aleksandra Ristic-Fira, Marcella Renis, Francesco P Romano, Francesco Romano, Giuseppe Schettino,
Francesco Schillaci, Valentina Scuderi, Concetta Stancampiano, Antonella Tramontana, Sargis TerAvetisyan, Barbara Tomasello, Lorenzo Torrisi, Salvo Tudisco, Andriy Velyhan.
ELIMED: A new hadron therapy concept based on laser driven ion beams. Proceedings of SPIE - The
International Society for Optical Engineering 2013-05, conference-paper DOI: 10.1117/12.2026530.
18. M Renis, M Borghesi, M Favetta, G Malfa, L Manti, F Romano, G Schettino, B Tomasello, GAP Cirrone.
Investigations of DNA damage induction and repair resulting from cellular exposure to high dose-rate
pulsed proton beams. AIP Conference Proceedings 2013, conference-paper DOI: 10.1063/1.4816615.
19. Luca Vanella, Ming Li, DongHyun Kim, Giuseppe Malfa, Lars Bellner, Tomoko Kawakami, Nader G
Abraham.
ApoA1: Mimetic peptide reverses adipocyte dysfunction in vivo and in vitro via an increase in
hemeoxygenase (HO-1) and Wnt10b.Cell Cycle 2012, journal-article DOI:10.4161/cc.11.4.19125.
20. Barbara Tomasello, Salvatore Grasso, Giuseppe Malfa, Stefania Stella, Marco Favetta, Marcella Renis.
Double-face activity of resveratrol in voluntary runners: Assessment of DNA damage by comet assay.
Journal of Medicinal Food 2012, journal-article DOI: 10.1089/jmf.2011.0173.
21. Pablo GA Cirrone, Giacomo Cuttone, Georg Korn, Mario Maggiore, Daniele Margarone, Bijan Bji,
Luciano Calabretta, Claudio Calí, Antonio Caruso, Fortunato Caruso, Salvatore Cavallaro, Santo
Gammino, Giuseppe Malfa, Lorenzo Manti, Santi Passarello, Jan Prokupek, Marcella Renis, Francesco
Romano, Francesco Schillaci, Barbara Tomasello, Lorenzo Torrisi, Antonella Tramontana, Biagio
Trovato, Emilio Zappalá.
ELIMED a new concept of hadrontherapy with laser-driven beams. IEEE Nuclear Science Symposium
Conference Record 2012, conference-paper DOI:10.1109/NSSMIC.2012.6551462.
22. Barbara Tomasello, Giuseppe Malfa, Fabio Galvano, Marcella Renis.
DNA damage in normal-weight obese syndrome measured by Comet assay. Mediterranean Journal
of Nutrition and Metabolism 2011, journal-article DOI: 10.1007/s12349-010-0035-6. Erratum: DNA
damage in normal-weight obese syndrome measured by Comet assay. Mediterranean Journal of
Nutrition and Metabolism 2011, journal-article DOI: 10.1007/s12349-010-0048-1.
23. Malfa G., Tomasello B., Spatafora C., Cardile V., Scifo C.,Tringali C., Renis M. Chemotherapeutic
effects of resveratrol and its analogue 3,5,4'-trans-trimethoxystilbene on DU145. Trends in Cancer
Research, vol 6 pp 45-54, 2010.
Books
1. Carotenoids as tools in breast cancer therapy
Loizzo M.R., Malfa G., Acquaviva R., Tundis R., Bonesi M.. Carotenoids as tools in breast cancer
therapy. Goutam Brahmachari. Vol. 5: Discovery and Development of Anti-Breast Cancerous Agents
from Natural Products. Elsevier Series ‘Natural Products Drug Discovery. 2018
2. Prevention and therapy of prostate cancer: the role of triterpene saponins
Bonesi M., Tundis R., Malfa G., Acquaviva R., Loizzo M.R. Prevention and therapy of prostate cancer:
the role of triterpene saponins. Goutam Brahmachari. Vol. 7: Discovery and Development of AntiProstate Cancerous Agents from Natural Products. Elsevier Series ‘Natural Products Drug Discovery.
2018
3. Citrus flavanones
Tundis R., Acquaviva R., Bonesi M., Malfa G.A., Tomasello B., Loizzo M.R
Handbook of Dietary Phytochemicals Chapter 5. In Press