Il crescente aumento delle infezioni microbiche è aggravato
dalla rapida emergenza e diffusione di cloni resistenti agli antibiotici e
spesso multi-drug-resistant (MDR), ovvero resistenti a più di tre classi
antibiotiche.



Il contenuto del modulo I del corso riflette la crescente
importanza del problema dell'antibiotico-resistenza correlato alla
disponibilità di nuovi antibiotici introdotti nella pratica clinica.



1. RESISTENZA
AGLI ANTIBIOTICI: UN PROCESSO CONTINUO:

- Diffusione
e trasferimento di geni della resistenza agli antibiotici (ARG) tra
uomo/animale/ambiente

- Il
modello “One-Health” per affrontare la resistenza agli antimicrobici (AMR)

- Strategie
di acquisizione delle resistenze agli antimicrobici (AMR) convenzionali.

- Meccanismi
di azione delle principali classi antibiotiche

- Nuovi
antibiotici

- Principali
“players” della Resistenza agli Antibiotici: i patogeni del gruppo ESKAPE




















Nel modulo II saranno ampliate ed
approfondite le conoscenze relative allo sviluppo biotecnologico e alle
modalità di applicazione di:





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{page:WordSection1;}2. STRATEGIE ALTERNATIVE PER COMBATTERE I PATOGENI
RESISTENTI AGLI ANTIBIOTICI:

- Riposizionamento
di vecchi farmaci

- Peptidi
Antimicrobici (AMP)

- Immunoterapici
e Vaccini

- Nanocomposti,
nanosensori e sistemi di drug-delivery

- Terapia
fagica

- CRISPR-Cas
system

- Inibitori
del Quorum-sensing

- Composti
antivirulenza3. SFIDE E PROSPETTIVE FUTURE





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1) Gianni Dehò e Enrica Galli. Biologia dei microrganismi. Casa editrice Ambrosiana.

2) Durante le lezioni sarà inoltre distribuito materiale integrativo (articoli scientifici da riviste internazionali) per l'approfondimento di tematiche specifiche.

3) https://www.ncbi.nlm.nih.gov/